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1. (WO2004058804) PEPTIDES AND THERAPEUTIC USES THEREOF
Dados bibliográficos mais recentes no arquivo da Secretaria Internacional   

№ de pub.:    WO/2004/058804    № do pedido internacional:    PCT/AU2003/001724
Data de publicação: 15.07.2004 Data de depósito internacional: 24.12.2003
Pedido de exame (capítulo 2) depositado:    25.06.2004    
CIP:
A61K 38/00 (2006.01), C07K 7/02 (2006.01), C07K 14/47 (2006.01)
Requerentes: WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH [AU/AU]; Royal Parade, Parkville, Victoria 3052 (AU) (For All Designated States Except US).
BAELL, Jonathan [AU/AU]; (AU) (For US Only).
HUANG, David [AU/AU]; (AU) (For US Only).
SMITH, Brian, John [AU/AU]; (AU) (For US Only).
STREET, Ian, Philip [AU/AU]; (AU) (For US Only)
Inventores: BAELL, Jonathan; (AU).
HUANG, David; (AU).
SMITH, Brian, John; (AU).
STREET, Ian, Philip; (AU)
Mandatário: MORRIS, Kathryn, B; Davies Collison Cave, 1 Nicholson Street, Melbourne, Victoria 3000 (AU)
Dados da prioridade:
2002953561 24.12.2002 AU
Título (EN) PEPTIDES AND THERAPEUTIC USES THEREOF
(FR) PEPTIDES ET UTILISATIONS THERAPEUTIQUES DE CEUX-CI
Resumo: front page image
(EN)Conformationally constrained peptides that mimic BH3-only proteins, compositions containing them and their use in the regulation of cell death are disclosed. The conformationally constrained peptides are capable of binding to and neutralising pro-survival Bcl-2 proteins. Processes for preparing the conformationally constrained peptides and their use in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.
(FR)L'invention concerne des peptides contraints par conformation mimant des protéines à 'BH3-seulement', des compositions les contenant ainsi que leur utilisation dans la régulation de la mort cellulaire. Ces peptides contraints par conformation peuvent se lier aux protéines de pro-survie Bcl-2 et les neutraliser. La présente invention concerne également des procédés permettant de préparer de tels peptides, ainsi que l'utilisation de ceux-ci pour traiter et/ou prévenir des maladies ou des affections associées à la dérégulation de la mort cellulaire.
Estados designados: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Língua de publicação: English (EN)
Língua de depósito: English (EN)