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1. (WO2006039739) HEPATITIS B VIRAL (HBV) MUTANTS DETECTION AND APPLICATION

Pub. No.:    WO/2006/039739    International Application No.:    PCT/AU2005/001538
Publication Date: Fri Apr 21 01:59:59 CEST 2006 International Filing Date: Fri Oct 07 01:59:59 CEST 2005
IPC: C12N 7/00
C12N 15/36
C12N 15/51
C12Q 1/70
Applicants: MELBOURNE HEALTH
BAYSIDE HEALTH
BARTHOLOMEUSZ, Angeline Ingrid
LOCARNINI, Stephen, Alister
AYRES, Anna
LEWIN, Sharon Ruth
SASADEUSZ, Joseph John
Inventors: BARTHOLOMEUSZ, Angeline Ingrid
LOCARNINI, Stephen, Alister
AYRES, Anna
LEWIN, Sharon Ruth
SASADEUSZ, Joseph John
Title: HEPATITIS B VIRAL (HBV) MUTANTS DETECTION AND APPLICATION
Abstract:
The present invention relates generally to viral variants exhibiting reduced sensitivity to agents and in particular one or more nucleoside or nucleotide analogs and/or non-nucleoside or non-nucleotide agents. More particularly, the present invention is directed to hepatitis B (HBV) variants RTh234Y and preS1 191V which correlate with a higher risk of an adverse disease outcome and exhibiting complete or partial resistance to abacavir (ABC) and lamividuine (LMV). The present invention further contemplates assays for detecting such viral variants which assays are useful in diagnosing a higher risk of an adverse disease outcome, in monitoring antiviral therapeutic regimes and in developing new or modified nucleoside or nucleotide analogs or non-nucleoside or non-nucleotide agents. The present invention also contemplates the use of viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus. Such agents are useful in treating hepatitis.