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1. (WO2013074596) HUMAN NOTCH RECEPTOR MUTATIONS AND THEIR USE

Pub. No.:    WO/2013/074596    International Application No.:    PCT/US2012/064969
Publication Date: Fri May 24 01:59:59 CEST 2013 International Filing Date: Thu Nov 15 00:59:59 CET 2012
IPC: C07H 21/00
G01N 33/48
Applicants: ONCOMED PHARMACEUTICALS, INC.
Inventors: CAIN, Jennifer, Anne
WANG, Min
KAPOUN, Ann, M.
HOEY, Timothy, C.
Title: HUMAN NOTCH RECEPTOR MUTATIONS AND THEIR USE
Abstract:
The present invention provides the identification and characterization of NOTCH mutations associated with enhanced receptor signaling. The present invention provides methods and kits for using the same. The present invention further provides methods of treating cancer in a patient having a solid tumor, wherein the solid tumor cells comprise an elevated level of NOTCH ICD.