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1. (WO2013074596) HUMAN NOTCH RECEPTOR MUTATIONS AND THEIR USE
Dados bibliográficos mais recentes no arquivo da Secretaria Internacional   

№ de pub.:    WO/2013/074596    № do pedido internacional:    PCT/US2012/064969
Data de publicação: 23.05.2013 Data de depósito internacional: 14.11.2012
CIP:
C07H 21/00 (2006.01), G01N 33/48 (2006.01)
Requerentes: ONCOMED PHARMACEUTICALS, INC. [US/US]; 800 Chesapeake Drive Redwood City, CA 94063 (US)
Inventores: CAIN, Jennifer, Anne; (US).
WANG, Min; (US).
KAPOUN, Ann, M.; (US).
HOEY, Timothy, C.; (US)
Mandatário: CALVO, Paul, A.; Sterne, Kessler, Goldstein & Fox, PLLC 1100 New York Avenue, NW Washington, DC 20005 (US)
Dados da prioridade:
61/560,627 16.11.2011 US
61/704,006 21.09.2012 US
Título (EN) HUMAN NOTCH RECEPTOR MUTATIONS AND THEIR USE
(FR) MUTATIONS DU RÉCEPTEUR NOTCH HUMAIN ET LEUR UTILISATION
Resumo: front page image
(EN)The present invention provides the identification and characterization of NOTCH mutations associated with enhanced receptor signaling. The present invention provides methods and kits for using the same. The present invention further provides methods of treating cancer in a patient having a solid tumor, wherein the solid tumor cells comprise an elevated level of NOTCH ICD.
(FR)La présente invention concerne l'identification et la caractérisation de mutations de NOTCH associées à une signalisation accrue par le récepteur. La présente invention concerne des procédés et des trousses pour l'utilisation associée. La présente invention concerne en outre des méthodes de traitement du cancer chez un patient présentant une tumeur solide, les cellules de tumeur solide comprenant un taux élevé du domaine intercellulaire (ICD) de NOTCH.
Estados designados: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Língua de publicação: English (EN)
Língua de depósito: English (EN)