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1. (WO1988006588) ANTIBIOTIC SULFONYLAMINOCARBONYL ACTIVATED $g(b)-LACTAMS
Dados bibliográficos mais recentes no arquivo da Secretaria Internacional   

№ de pub.:    WO/1988/006588    № do pedido internacional:    PCT/US1988/000404
Data de publicação: 07.09.1988 Data de depósito internacional: 19.02.1988
Pedido de exame (capítulo 2) depositado:    09.09.1988    
CIP:
C07D 417/14 (2006.01)
Requerentes: THE UPJOHN COMPANY [US/US]; 301 Henrietta Street, Kalamazoo, MI 49001 (US) (For All Designated States Except US).
BARBACHYN, Michael, R. [US/US]; (US) (For US Only).
BRICKNER, Steven, J. [US/US]; (US) (For US Only).
THOMAS, Richard, C. [US/US]; (US) (For US Only)
Inventores: BARBACHYN, Michael, R.; (US).
BRICKNER, Steven, J.; (US).
THOMAS, Richard, C.; (US)
Mandatário: BUSSE, Paul, W.; Patent Law Department, The Upjohn Company, Kalamazoo, MI 49001 (US).
PERRY, Robert, E.; Gill Jennings & Every, 53-64 Chancery Lane, London WC2A 1HN (GB)
Dados da prioridade:
021,094 03.03.1987 US
023,403 09.03.1987 US
024,948 12.03.1987 US
026,925 17.03.1987 US
065,431 23.06.1987 US
Título (EN) ANTIBIOTIC SULFONYLAMINOCARBONYL ACTIVATED $g(b)-LACTAMS
(FR) $g(b)-LACTAMES ANTIBIOTIQUES ACTIVES AVEC DU SULFONYLAMINOCARBONYLE
Resumo: front page image
(EN)This invention presents novel 2-azetidinone compounds which are useful as antibacterial agents to eradicate or control susceptible microbes of formula (I), wherein R¿401? and R¿402? are the same or different and are a) hydrogen, b) (C¿1?-C¿12?) alkyl c) (C¿2?-C¿8?) alkenyl, d) (C¿2?-C¿8?) alkynyl, e) (C¿3?-C¿10?) cycloalkyl, f) phenyl optionally substituted with from one to 3 substituents selected from the group consisting of halogen, hydroxy, amino, nitro, (C¿1?-C¿4?) alkyl, and (C¿1?-C¿4?) alkoxy, g) benzyl optionally substituted with from one to 3 substituents selected from the group consisting of halogen, hydroxy, amino, nitro (C¿1?-C¿4?) alkyl, and (C¿1?-C¿4?) alkoxy, h) -CH¿2?-O-CO-CH¿2?-NHR¿420?, i) -CH¿2?-O-CO¿2?-R¿430?, j) -CH¿2?F, or k) -CHF¿2?; wherein R¿420? is a) hydrogen, b) -COH, or c) -CO-O-C(CH¿3?)¿3?; wherein R¿430? is (C¿1?-C¿8?) alkyl, -(CH¿2?)¿2?OC(O)NH¿2?, -(CH¿2?)¿2?Cl, -(CH¿2?)¿2?OCH¿3? or -(CH¿2?)¿2?NHCOH; wherein R¿300? is an acyl group derived from a carboxylic acid; wherein R¿100? is an optionally substituted heterocyclic moiety.
(FR)Des composés nouveaux de 2-azétidinone utiles comme agents bactéricides pour éliminer ou réduire des microbes sensibles à ces composés ont la formule (I), dans laquelle R¿401? et R¿402? sont différents ou identiques et sont a) hydrogène, b) (C¿1?-C¿12?) alkyl, c) (C¿2?-C¿8?) alkényle, d) (C¿2?-C¿8?) alkynyle, e) (C¿3?-C¿10?) cycloalkyl, f) phényle éventuellement substitué avec un à trois substituants sélectionnés dans le groupe formé d'halogène, hydroxyle, amine, nitro, (C¿1?-C¿4?) alkyl et (C¿1?-C¿4?) alkoxy, h) -CH¿2?-O-CO-CH¿2?-NHR¿420?, i) -CH¿2?-O-CO¿2?-R¿430?, j) -CH¿2?F ou k) -CHF¿2?; dans laquelle R¿420? est a) hydrogène, b) -COH, ou c) -CO-O-C(CH¿3?)¿3? dans laquelle R¿430? est (C¿1?-C¿8?) alkyl, -(CH¿2?)¿2?OC(O)NH¿2?, -(CH¿2?)¿2?Cl, -(CH¿2?)¿2?OCH¿3? ou -(CH¿2?)¿2?NHCOH; dans laquelle R¿300? est un groupe acyle dérivé d'un acide carboxylique et R¿100? est une moitié hétérocyclique éventuellement substituée.
Estados designados: AU, DK, FI, JP, KR, NO.
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE).
Língua de publicação: English (EN)
Língua de depósito: English (EN)