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기계 번역
12. (CA2836915) EMETINE DERIVATIVES, PRODRUGS CONTAINING SAME, AND METHODS OF TREATING CONDITIONS USING SAME

출원번호: 2836915 출원일:
공개번호: 2836915 공개일: 29.11.2012
공개유형: A1
PCT 참조번호: 출원번호: PCTUS2012038655; 공개번호: 자료를 보려면 여기를 클릭하십시오
IPC:
C07K 7/06
A61K 31/4725
A61K 47/48
A61P 35/00
A61P 35/04
C07D 455/08
C07K 5/062
CPC:
A61K 47/48338
C07D 401/06
C07D 455/08
출원인: HOWARD UNIVERSITY
발명자:
우선권 정보 61/488,601 20.05.2011 US
발명의 명칭: (FR) DERIVES D'EMETINE, PRODROGUES CONTENANT CES DERIVES ET PROCEDES DE TRAITEMENT DE TROUBLES AU MOYEN DE CES PRODROGUES
(EN) EMETINE DERIVATIVES, PRODRUGS CONTAINING SAME, AND METHODS OF TREATING CONDITIONS USING SAME
요약서:
(EN) Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2'-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.