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1. (WO2019033203) METHOD FOR DETERMINATION OF CELLULAR MRNA
국제사무국에 기록된 최신 서지정보정보 제출

공개번호: WO/2019/033203 국제출원번호: PCT/CA2018/050977
공개일: 21.02.2019 국제출원일: 13.08.2018
IPC:
C12Q 1/6813 (2018.01) ,C12M 1/34 (2006.01) ,C12Q 1/6809 (2018.01) ,C12Q 1/6876 (2018.01) ,C12Q 1/6886 (2018.01) ,G06F 19/20 (2011.01)
[IPC code unknown for C12Q 1/6813]
C SECTION C — 화학; 야금
12
생화학; 맥주; 주정; 포도주; 식초; 미생물학; 효소학; 돌연변이 또는 유전자공학
M
효소학 또는 미생물학을 위한 장치
1
효소학 또는 미생물학을 위한 장치
34
상태의 측정 또는 검출수단으로 측정 또는 시험을 행하는 것, 예. 콜로니 계수기
[IPC code unknown for C12Q 1/6809][IPC code unknown for C12Q 1/6876][IPC code unknown for C12Q 1/6886]
G SECTION G — 물리학
06
산술논리연산; 계산; 계수
F
전기에 의한 디지털 데이터처리
19
특수한 어플리케이션에 특히 적합한 디지털 컴퓨팅 또는 데이터 처리 장치 또는 방법
10
생물정보학, 즉 컴퓨터 분자 생물학에서 유전 또는 단백질 관련 데이터 처리를 위한 수단 또는 시스템
20
교배 또는 유전자 표현에 대한 것, 예. 극소 배열, 교배의 순서, 규격화, 자료수집, 잡음 수정 모델, 표현 비율 예측, 프로브 디자인 또는 프로브 최적화
출원인:
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO [CA/CA]; 27 King's College Circle Toronto, Ontario M5S 1A1, CA
발명자:
LABIB, Mahmoud; CA
SARGENT, Edward H.; CA
KELLEY, Shana O.; CA
대리인:
RIDOUT & MAYBEE LLP; 250 University Avenue, 5th Floor Toronto, Ontario M5H 3E5, CA
WONG, Christine; CA
우선권 정보:
62/545,08114.08.2017US
발명의 명칭: (EN) METHOD FOR DETERMINATION OF CELLULAR MRNA
(FR) PROCÉDÉ DE DÉTERMINATION D’ARNM CELLULAIRE
요약서:
(EN) Methods and systems for mRNA analysis and quantification of mRNA expression in cells are provided. An example method includes introducing a first capture probe and a second capture probe into the cells, the first capture probe and the second capture probe each configured to be complementary to a respective section of target mRNA within the cells, wherein binding of the first and second capture probes to the respective sections of the target mRNA results in tagging of the cells and causes the first and second capture probes to form clusters with each other. The first capture probe and the second capture probe are each bound to magnetic nanoparticles (MNPs) that, when trapped within the tagged cells, cause the tagged cells to be susceptible to magnetic forces. The method and system further include introducing the cells into a device configured to magnetically capture tagged cells.
(FR) La présente invention concerne des procédés et des systèmes d’analyse d’ARNm et de quantification de l’expression de l’ARNm dans des cellules. Un procédé donné à titre d'exemple comprend l’introduction d’une première sonde de capture et d’une seconde sonde de capture dans les cellules, la première sonde de capture et la seconde sonde de capture étant chacune configurées pour être complémentaires d’une section respective d’un ARNm cible dans les cellules, la liaison de la première et de la seconde sonde de capture aux sections respectives de l’ARNm cible entraînant le marquage des cellules et amenant la première et la seconde sonde de capture à former des amas l'une avec l'autre. La première sonde de capture et la seconde sonde de capture sont chacune liées à des nanoparticules magnétiques (MNP) qui, lorsqu’elles sont piégées à l’intérieur des cellules marquées, amènent les cellules marquées à être sensibles aux forces magnétiques. Le procédé et le système comprennent en outre l’introduction des cellules dans un dispositif configuré pour capturer magnétiquement les cellules marquées.
front page image
지정국: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
아프리카지역 지식재산권기구(ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
유라시아 특허청(EAPO) (AM, AZ, BY, KG, KZ, RU, TJ, TM)
유럽 특허청(EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
아프리카 지식재산권기구(OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
공개언어: 영어 (EN)
출원언어: 영어 (EN)