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1. (WO2019000910) METHOD FOR PREPARING 2-FLUOROACRYLATE
국제사무국에 기록된 최신 서지정보    정보 제출

공개번호: WO/2019/000910 국제출원번호: PCT/CN2018/072199
공개일: 03.01.2019 국제출원일: 11.01.2018
IPC:
C07C 67/08 (2006.01) ,C07C 67/14 (2006.01) ,C07C 69/653 (2006.01)
C SECTION C — 화학; 야금
07
유기화학
C
비환 화합물 또는 탄소환 화합물
67
카르복시산 에스테르의 제조
08
.카르복시산 또는 대칭무수물과 유기화합물의 수산기 또는 O - 금속기와의 반응에 의한 것
C SECTION C — 화학; 야금
07
유기화학
C
비환 화합물 또는 탄소환 화합물
67
카르복시산 에스테르의 제조
14
.카르복시산할로겐화물로부터의 것
C SECTION C — 화학; 야금
07
유기화학
C
비환 화합물 또는 탄소환 화합물
69
카르복시산의 에스테르; 탄산 또는 할로포름산의 에스테르
62
.할로겐을 함유하는 에스테르
65
불포화된 산의
653
메타크릴산 에스테르; 아크릴산 에스테르; 할로아크릴산 에스테르; 할로메타크릴산 에스테르
출원인:
临海天宇药业有限公司 LINHAI TIANYU PHARMACEUTICAL CO., LTD. [CN/CN]; 中国浙江省 化学原料药基地临海园区东海第五大道15号 No.15 The East China Sea Fifth Avenue, Lin Hai Park, Chemical Raw Material Base Zhejiang 317016, CN
上海新埠医药科技有限公司 SHANGHAI XINBU MEDICINE SCIENCE & TECHNOLOGY CO., LTD. [CN/CN]; 中国上海市 徐汇区华泾路1305弄18号B座4楼 4/F, Block B, No.18, Alley 1305, Huajing Road, Xuhui District Shanghai 200231, CN
발명자:
仇昆伦 QIU, Kunlun; CN
王文博 WANG, Wenbo; CN
於钱杰 YU, Qianjie; CN
李波涛 LI, Botao; CN
练雄东 LIAN, Xiongdong; CN
李功勇 LI, Gongyong; CN
대리인:
上海专利商标事务所有限公司 SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC; 中国上海市 桂平路435号 435 Guiping Road Shanghai 200233, CN
우선권 정보:
201710505701.428.06.2017CN
발명의 명칭: (EN) METHOD FOR PREPARING 2-FLUOROACRYLATE
(FR) PROCÉDÉ DE PRÉPARATION DE 2-FLUOROACRYLATE
(ZH) 一种2-氟丙烯酸酯的制备方法
요약서:
(EN) Disclosed is a method for preparing a 2-fluoroacrylate, using the following steps: (1) a vinyl ether with a structure as shown in formula A is mixed with monofluorodichloromethane to obtain a substituted cyclopropane compound with a structure as shown in formula B; (2) the substituted cyclopropane compound with the structure as shown in formula B is mixed with R2OH to obtain an acetal product with a structure as shown in formula C, and the acetal product is then hydrolyzed to obtain a 2-fluoroacrolein with a structure as shown in formula D; or the substituted cyclopropane compound with the structure as shown in formula B is reacted with water for cracking to obtain the 2-fluoroacrolein with the structure as shown in formula D; (3) the 2-fluoroacrolein with the structure as shown in formula D is oxidized to obtain a 2-fluoroacrylic acid with a structure as shown in formula E; and (4) the 2-fluoroacrylic acid with the structure as shown in formula E is mixed with R3OH to obtain a 2-fluoroacrylate with a structure as shown in formula F.
(FR) La présente invention concerne un procédé de préparation de 2-fluoroacrylate comprenant les étapes suivantes : (1) un éther de vinyle ayant une structure représentée par la formule A est mélangé avec du monofluorodichlorométhane pour obtenir un composé de cyclopropane substitué ayant une structure représentée par la formule B; (2) le composé de cyclopropane substitué ayant la structure de formule B est mélangé avec R2OH pour obtenir un produit d'acétal ayant une structure de formule C, et le produit acétal est ensuite hydrolysé pour obtenir du 2-fluoroacroléine ayant une structure de formule D; ou le composé de cyclopropane substitué ayant la structure de formule B est mis à réagir avec de l'eau pour le craquage afin d'obtenir du 2-fluoroacroléine ayant la structure de formule D; (3) la 2-fluoroacroléine ayant la structure de formule D est oxydée pour obtenir un acide 2-fluoroacrylique ayant une structure de formule E; et (4) l'acide 2-fluoroacrylique ayant la structure de formule E est mélangé avec R3OH pour obtenir du 2-fluoroacrylate ayant une structure de formule F.
(ZH) 2-氟丙烯酸酯的制备方法,采用如下步骤:(1)将结构如式A所示的乙烯基醚和一氟二氯甲烷混合,得到结构如式B所示的取代环丙烷化合物;(2)将结构如式B所示的取代环丙烷化合物和R2OH混合得到结构如式C所示的缩醛产物后水解得到结构如式D所示的2-氟丙烯醛;或将结构如式B所示的取代环丙烷化合物和水反应裂解得到结构如式D所示的2-氟丙烯醛;(3)使结构如式D所示的2-氟丙烯醛经氧化得到结构如式E所示的2-氟丙烯酸;和(4)结构如式E所示的2-氟丙烯酸和R3OH混合得到如式F所示的2-氟丙烯酸酯。
지정국: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
아프리카지역 지식재산권기구(ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
유라시아 특허청 (AM, AZ, BY, KG, KZ, RU, TJ, TM)
유럽 특허청(EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
공개언어: 중국어 (ZH)
출원언어: 중국어 (ZH)