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1. (WO2018220589) FLOW MODIFICATION IN BODY LUMENS
유의사항: 이 문서는 자동 광학문자판독장치(OCR)로 처리된 텍스트입니다. 법률상의 용도로 사용하고자 하는 경우 PDF 버전을 사용하십시오

WHAT IS CLAIMED IS:

1. An implantable device for altering fluid flow through a body lumen, the body lumen coupled to a branch lumen, the implantable device comprising:

a flow modulator configured to be implanted within the body lumen, the flow modulator comprising an upstream component separated by a gap from a downstream component, the upstream component having an inlet, an outlet, and a cross-sectional flow area that converges from the inlet towards the outlet, the downstream component having an entry, an exit, and a cross-sectional flow area that diverges from the entry towards the exit, the outlet of the upstream component being a distance less than 15 mm from the entry of the downstream component, wherein the gap defines a pathway that communicates with the branch lumen,

wherein the flow modulator is configured to accelerate a fluid stream passing through the upstream component towards the downstream component to generate a low pressure region in the vicinity of the gap and to entrain additional fluid into the fluid stream as the fluid stream passes into the entry of the downstream component.

2. The implantable device of claim 1, wherein the cross-sectional flow area at the outlet of the upstream component is less than the cross-sectional flow area at the entry of the downstream component.

3. The implantable device of claim 1, wherein the outlet of the upstream component is positioned downstream from where the branch lumen first intersects with the body lumen.

4. The implantable device of claim 1, wherein the gap begins downstream from where the branch lumen first intersects with the body lumen.

5. The implantable device of claim 1, wherein the upstream component and the downstream component share a common, collinear flow axis with the body lumen's flow axis.

6. The implantable device of claim 1, wherein the outlet of the upstream component is positioned downstream from the entry of the downstream component.

7. The implantable device of claim 1, wherein the upstream component is coupled to the downstream component via a fluid flow structure that defines the gap,

wherein the upstream component, the downstream component, and the fluid flow structure are formed from a single frame.

8. The implantable device of claim 7, wherein the fluid flow structure extends outward from the upstream component and from the downstream component such that the fluid flow structure contacts an inner wall of the body lumen.

9. The implantable device of claim 7, wherein a junction between the fluid flow structure and at least one of the upstream component or the downstream component has an S-curve shape.

10. The implantable device of claim 1, wherein the downstream component's length is greater than the upstream component's length.

11. The implantable device of claim 1, wherein the upstream component's average angle of convergence is greater than the downstream component's average angle of divergence.

12. The implantable device of claim 1, wherein the upstream component comprises a nozzle that accelerates the fluid stream passing through the upstream component and the downstream component comprises a diffuser that decelerates the fluid stream having the entrained additional fluid passing through the downstream component.

13. An implantable device for altering fluid flow through a body lumen, the body lumen coupled to a branch lumen, the implantable device comprising:

a flow modulator configured to be implanted within the body lumen, the flow modulator comprising an upstream component separated by a gap from a downstream component, the upstream component having an inlet, an outlet, and a cross-sectional flow area that converges from the inlet towards the outlet, the downstream component having an entry, an exit, and a cross-sectional flow area that diverges from the entry towards the exit, the cross-sectional flow area at the outlet being less than the cross-sectional flow area at the entry, wherein the gap defines a pathway that communicates with the branch lumen,

wherein the flow modulator is configured to accelerate a fluid stream passing through the upstream component towards the downstream component to generate a low pressure region in the vicinity of the gap and to entrain additional fluid into the fluid stream as the fluid stream passes into the entry of the downstream component.

14. The implantable device of claim 13, the outlet of the upstream component is positioned downstream from where the branch lumen first intersects with the body lumen.

15. The implantable device of claim 13, wherein the gap begins downstream from where the branch lumen first intersects with the body lumen.

16. The implantable device of claim 13, wherein the outlet of the upstream component is positioned downstream from the entry of the downstream component.

17. The implantable device of claim 13, wherein the upstream component is coupled to the downstream component via a fluid flow structure that defines the gap.

18. The implantable device of claim 13, wherein the flow modulator is formed from a metal frame.

19. The implantable device of claim 18, wherein the metal frame is coated with a biocompatible material at the upstream component and at the downstream component.

20. A method for altering fluid flow through a body lumen, the body lumen coupled to a branch lumen, the method comprising:

implanting a flow modulator within a body lumen, the flow modulator comprising an upstream component separated by a gap from a downstream component, the upstream component being implanted in a first body lumen portion and having an inlet, an outlet, and a cross-sectional flow area that converges from the inlet towards the outlet, the downstream component being implanted in a second body lumen portion and having an entry, an exit, and a cross-sectional flow area that diverges from the entry towards the exit, and the gap being positioned where the branch lumen intersects with the body lumen and the outlet being positioned downstream from where the branch lumen first intersects with the body lumen; and

accelerating a fluid stream passing through the upstream component towards the downstream component to generate a low pressure region in the vicinity of the gap and to entrain additional fluid into the fluid stream as the fluid stream passes into the entry of the downstream component.

21. The method of claim 20, wherein implanting the flow modulator within the body lumen comprises implanting the upstream component in an inferior vena cava such that the inlet is upstream from a branch off to a renal vein and the downstream component in the inferior vena cava such that the exit is downstream from the branch off to the renal vein, wherein the gap is at the branch to the renal vein, thereby drawing blood to the renal vein and improving kidney functionality.

22. The method of claim 21, wherein drawing the blood to the renal vein to improve kidney functionality further reduces excess fluid to treat heart failure.

23. The method of claim 20, wherein the flow modulator modulates fluid flow without any input from an external energy source.

24. The method of claim 20, wherein the flow modulator modulates fluid flow without any moving parts.