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1. (WO2017143152) NASAL BIOMARKERS OF ASTHMA

Pub. No.:    WO/2017/143152    International Application No.:    PCT/US2017/018318
Publication Date: Fri Aug 25 01:59:59 CEST 2017 International Filing Date: Sat Feb 18 00:59:59 CET 2017
IPC: C12Q 1/68
G01N 33/48
C40B 40/08
Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Inventors: BUNYAVANICH, Supinda
PANDEY, Gaurav
SCHADT, Eric, S.
Title: NASAL BIOMARKERS OF ASTHMA
Abstract:
Asthma is a common, under-diagnosed disease affecting all ages. Mild to moderate asthma is particularly difficult to diagnose given currently available tools. A nasal biomarker of asthma is of high interest given the accessibility of the nose and shared airway biology between the upper and lower respiratory tract. A machine learning pipeline identified an asthma gene panel of 275 unique nasally-expressed genes interpreted via different classification models. This asthma gene panel can be utilized to reliably diagnose asthma in patients, including mild to moderate asthma, in a non-invasive manner and to distinguish asthma from other respiratory disorders, allowing appropriate treatment of the patient's asthma.