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1. (WO2017001020) HOPS-BASED SUBSTANCE AND USE OF THE SUBSTANCE
국제사무국에 기록된 최신 서지정보

공개번호: WO/2017/001020 국제출원번호: PCT/EP2015/065107
공개일: 05.01.2017 국제출원일: 02.07.2015
IPC:
A61K 31/121 (2006.01) ,A61K 31/122 (2006.01) ,A61P 1/16 (2006.01)
A SECTION A — 생활필수품 농업
61
위생학; 의학 또는 수의학
K
의약용, 치과용 또는 화장용 제제
31
유기 활성 성분을 함유 하는 의약품 제재
12
케톤
121
비환식
A SECTION A — 생활필수품 농업
61
위생학; 의학 또는 수의학
K
의약용, 치과용 또는 화장용 제제
31
유기 활성 성분을 함유 하는 의약품 제재
12
케톤
122
환에 직접 결합한 산소원자를 가지는 것, 예. 퀴논, 비타민 K1, 안트라린
A SECTION A — 생활필수품 농업
61
위생학; 의학 또는 수의학
P
화합물 또는 의약품 제제의 특정한 치료효과
1
소화관 또는 소화기계 질환용 의약
16
간장 또는 담낭 질환용 의약, 예. 간 보호제, 이담제, 결석용해제
출원인:
FLAXAN GMBH & CO. KG [DE/DE]; Freiligrathstr. 7/9 90482 Nürnberg, DE
발명자:
HELLERBRAND, Claus; DE
대리인:
STIPPL, Hubert; Stippl Patentanwälte Freiligrathstraße 7a 90482 Nürnberg, DE
우선권 정보:
발명의 명칭: (DE) SUBSTANZ AUF HOPFENBASIS SOWIE VERWENDUNG DER SUBSTANZ
(EN) HOPS-BASED SUBSTANCE AND USE OF THE SUBSTANCE
(FR) SUBSTANCE À BASE DE HOUBLON ET UTILISATION DE DE LADITE SUBSTANCE
요약서:
(DE) Die vorliegende Erfindung betrifft eine Substanz auf Hopfenbasis, welche ein Gemisch von (a) Xanthohumol mit der Formel (I) sowie (b) mindestens einer isomerisierten Hopfensäure, vorzugsweise Iso-alpha-Säure jeweils in angereicherter oder isolierter Form umfasst. Es hat sich überraschend gezeigt, dass eine Substanz, bei der Xanthohumol sowie Iso-alpha-Säure in Kombination sowie jede Substanz jeweils in angereicherter oder isolierter Form in der Kombination vorliegend, die Wirksamkeit in Zusammenhang mit der Vorbeugung und/oder Bekämpfung von Lebererkrankungen bzw. Leberschädigungen im Vergleich zu Xanthohumol allein beträchtlich steigert. Die entzündungshemmende, Fibrosierungs-hemmende Wirkung von Xanthohumol sowie die Hemmung auf die Verfettung von Leberzellen wird somit durch das Vorhandensein von Iso-alpha-Säure überraschend erhöht.
(EN) The invention relates to a hops-based substance which comprises a mixture of (a) xanthohumol of the formula (I) and (b) at least one isomerized hops acid, preferably iso-alpha acid, in each case in an enriched or isolated form. It has surprisingly been shown that a substance in which xanthohumol and iso-alpha acid are present in combination and in which each substance is present in an enriched or isolated form in the combination substantially increases the efficacy in relation to the prevention and/or control of liver diseases or liver damage compared to xanthohumol alone. The inflammation- and fibrosis-inhibiting effect of xanthohumol and the inhibition of the fatty changes of liver cells is thus increased by the presence of iso-alpha acid.
(FR) L'invention concerne une substance à base de houblon, qui comprend un mélange de (a) xanthohumol de formule (I) et de (b) au moins un acide de houblon isomérisé, de préférence un iso-alpha-acide respectivement sous une forme enrichie ou isolée. Il s'est avéré de façon inattendue qu'une substance, comprenant du xanthohumol et de l'iso-alpha-acide en combinaison ainsi que toute substance présente respectivement sous une forme enrichie ou isolée dans la combinaison, augmentait considérablement l'efficacité relative à la prévention et/ou la lutte contre les affections hépatiques et/ou les lésions hépatiques, par rapport au xanthohumol seul. L'effet anti-inflammatoire et antifibrotique du xanthohumol et l'inhibition de la dégénérescence graisseuse des cellules hépatiques sont accrus de manière étonnante grâce à la présence d'iso-alpha-acide.
front page image
지정국: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
아프리카지역 지식재산권기구(ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
유라시아 특허청(EAPO) (AM, AZ, BY, KG, KZ, RU, TJ, TM)
유럽 특허청(EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
아프리카 지식재산권기구(OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
공개언어: 독일어 (DE)
출원언어: 독일어 (DE)
또한로 출판 됨:
US20180193287