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1. (WO2008031051) CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF HUMAN SERUM PROTEIN BIOMARKERS
국제사무국에 기록된 최신 서지정보

공개번호: WO/2008/031051 국제출원번호: PCT/US2007/077911
공개일: 13.03.2008 국제출원일: 07.09.2007
IPC:
G01N 33/68 (2006.01) ,G01N 33/576 (2006.01)
G SECTION G — 물리학
01
측정; 시험
N
재료의 화학적 또는 물리적 성질의 검출에 의한 재료의 조사 또는 분석
33
그룹 1/00 ~ 31/00에 포함 되지 않는 특유의 방법에 의한 재료의 조사 또는 분석
48
생물학적재료, 예. 혈액, 소변 혈구계
50
생물학적 재료의 화학적분석, 예. 혈액, 오줌; 생물학적특이성을 갖는 배위자 결합방법을 포함한 시험 면역학적시험
68
단백질 또는 펩타이드(peptide) 또는 아미노산을 함유하는 것
G SECTION G — 물리학
01
측정; 시험
N
재료의 화학적 또는 물리적 성질의 검출에 의한 재료의 조사 또는 분석
33
그룹 1/00 ~ 31/00에 포함 되지 않는 특유의 방법에 의한 재료의 조사 또는 분석
48
생물학적재료, 예. 혈액, 소변 혈구계
50
생물학적 재료의 화학적분석, 예. 혈액, 오줌; 생물학적특이성을 갖는 배위자 결합방법을 포함한 시험 면역학적시험
53
면역분석; 생물학적 특이적 결합분석; 그것을 위한 물질
576
간염에 대한 것
출원인:
UNITED THERAPEUTICS CORPORATION [US/US]; 1110 Spring Street Silver Spring, MD 20910, US (AllExceptUS)
GANGADHARAN, Bevin [GB/GB]; GB (UsOnly)
ZITZMANN, Nicole [DE/GB]; US (UsOnly)
DWEK, Raymond, A. [GB/GB]; US (UsOnly)
발명자:
GANGADHARAN, Bevin; GB
ZITZMANN, Nicole; US
DWEK, Raymond, A.; US
대리인:
MAEBIUS, Stephen, B. ; Foley & Lardner LLP Washington Harbor 3000 K St, NW Suite 500 Washington, DC 20007, US
우선권 정보:
60/842,98008.09.2006US
발명의 명칭: (EN) CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF HUMAN SERUM PROTEIN BIOMARKERS
(FR) DIAGNOSTIC CLINIQUE D'UNE FIBROSE HÉPATIQUE EN UTILISANT UNE NOUVELLE NUMÉRATION GLOBULAIRE DE BIOMARQUEURS DE PROTÉINES DU SÉRUM HUMAIN
요약서:
(EN) The inventors have proposed a novel panel of human serum protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-P AGE based proteomics study was used to identify potential fibrosis biomarkers. Serum from patients with varying degrees of hepatic scarring induced by infection with the hepatitis C virus (HCV) was analysed. Several proteins associated with liver scarring and/or viral infection were identified. These proteins include the inter-α-trypsin inhibitor heavy chain H4 fragments, complement factor H-related protein 1, CD5L, Apo Ll, and β2GPI. Increased and decreased thiolester cleavage of a2M and Complement C3, respectively, was also detected. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers.
(FR) L'invention concerne une nouvelle numération globulaire de biomarqueurs de protéines du sérum humain pour diagnostiquer une fibrose hépatique et une cirrhose. Actuellement, il n'y a pas de manière non invasive fiable pour évaluer une fibrose du foie. Une étude protéomique basée sur 2D-PAGE a été utilisée pour identifier des biomarqueurs de fibrose potentiels. Du sérum provenant de patients ayant des degrés variables de cicatrisation hépatique induite par infection avec le virus de l'hépatite C (HCV) a été analysé. Plusieurs protéines associées à une cicatrisation du foie et/ou une infection virale ont été identifiées. Ces protéines comprennent les fragments H4 de la chaîne lourde de l'inhibiteur de la trypsine inter-a, une protéine en rapport avec le facteur H de protéine 1, CD5L, Apo L1 et b2GPI. On a également détecté un clivage de thiolester augmenté et diminué de a2M et du complément C3, respectivement. Les concentrations de ces nouveaux biomarqueurs peuvent être déterminées en utilisant un immunoessai où les concentrations vont refléter l'étendue de la fibrose. Une échelle de quantification de fibrose pour chacun des nouveaux biomarqueurs est proposée. Le résultat supplémentaire provenant des scores de tous les nouveaux biomarqueurs va donner une indication plus fiable du degré de fibrose plutôt que d'examiner des biomarqueurs individuels.
front page image
지정국: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
아프리카지역 지식재산권기구(ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
유라시아 특허청(EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
유럽 특허청(EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
아프리카 지식재산권기구(OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
공개언어: 영어 (EN)
출원언어: 영어 (EN)