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1. (WO2007124478) METHOD AND SYSTEM FOR PREPARING SOFT TISSUE FOR GRAFTING, ENHANCING GRAFTING RESULTS, AND GRAFTING AUTOLOGOUS FAT AND ADIPOCYTE DERIVED STEM CELLS TO SOFT TISSUE SUCH AS THE BREAST AND OTHER TISSUE DEFECTS
국제사무국에 기록된 최신 서지정보

공개번호: WO/2007/124478 국제출원번호: PCT/US2007/067202
공개일: 01.11.2007 국제출원일: 23.04.2007
IPC:
A61K 48/00 (2006.01) ,C12N 5/00 (2006.01)
A SECTION A — 생활필수품 농업
61
위생학; 의학 또는 수의학
K
의약용, 치과용 또는 화장용 제제
48
유전자 질병을 치료하기 위해 생체의 세포 내에 삽입하는 유전자 물질을 함유하는 의료용제제; 유전자 치료
C SECTION C — 화학; 야금
12
생화학; 맥주; 주정; 포도주; 식초; 미생물학; 효소학; 돌연변이 또는 유전자공학
N
미생물 또는 효소; 그 조성물; 미생물의 보존, 유지, 증식; 돌연변이 또는 유전자공학; 배지
5
인체 , 동물 또는 식물의 미분화세포, 예. 세포주; 조직; 그것의 배양 또는 유지; 그것의 배지
출원인:
KHOURI, Roger K. [US/US]; US
발명자:
KHOURI, Roger K.; US
대리인:
HAFERKAMP, Richard E. ; Thompson Coburn, LLP One US Bank Plaza St. Louis, MO 63101, US
우선권 정보:
11/409,29421.04.2006US
발명의 명칭: (EN) METHOD AND SYSTEM FOR PREPARING SOFT TISSUE FOR GRAFTING, ENHANCING GRAFTING RESULTS, AND GRAFTING AUTOLOGOUS FAT AND ADIPOCYTE DERIVED STEM CELLS TO SOFT TISSUE SUCH AS THE BREAST AND OTHER TISSUE DEFECTS
(FR) PROCÉDÉ ET SYSTÈME DE PRÉPARATION DE TISSUS MOUS EN VUE D'UNE GREFFE, AMÉLIORATION DES RÉSULTATS DE GREFFE, ET GREFFE AUTOLOGUE DE CELLULES SOUCHES DÉRIVÉES DU TISSU ADIPEUX ET DES ADIPOCYTES À UN TISSU MOU TEL QUE LE TISSU MAMMAIRE ET D'AUTRES DÉFAUTS TISSULAIRES
요약서:
(EN) A method is disclosed for preparing a soft tissue site, and augmenting the soft tissue site, such as the breast(s), scar, depression, or other defect, of a subject through use of devices that exert a distractive force on the breast(s) and grafting of autologous fat tissue such as domes with sealing rims for surrounding each of the soft tissue site and a regulated pump. The method for preparing the soft tissue site, and enhancing fat graft results, entails application of the distracting force to the targeted soft tissue site at least intermittently for some period of time and preferably several weeks prior to the graft procedure. A related aspect of the invention includes following the preparation steps by transfer of fat from other areas of the subject to the subject's soft tissue site, and then reapplication of the distractive force to the soft tissue site that received the autologous fat graft. Alternatively, fat from genetically related sources may be used, and the fat may be further processed prior to injection. Substantial soft tissue augmentation, high rates of graft survival and negligible graft necrosis (data demonstrating 80% survival and only 20% necrosis is presented) or calcification result from the practice of these methods.
(FR) L'invention concerne un procédé permettant de préparer un site tissulaire mou, d'augmenter le site tissulaire mou, par exemple le tissu mammaire, une cicatrice, un creux ou un autre défaut, chez un sujet en utilisant des dispositifs qui exercent une force de distension du tissu mammaire et en greffant du tissu adipeux autologue, tel que des dômes avec des bords étanches afin d'entourer chaque site tissulaire mou, et une pompe régulée. Le procédé de préparation du site tissulaire mou et d'amélioration des résultats de greffe de tissu adipeux implique d'appliquer la force de distension au site tissulaire mou ciblé au moins par intermittence pendant une certaine durée, de préférence plusieurs semaines, avant l'opération de greffe. Un aspect apparenté de l'invention consiste à suivre les étapes de préparation en transférant du tissu adipeux provenant d'autres zones du sujet au site tissulaire mou du sujet et ensuite à appliquer de nouveau la force de distension au site tissulaire mou ayant reçu la greffe de tissu adipeux autologue. En variante, il est possible d'utiliser du tissu adipeux provenant de sources génétiquement apparentées et le tissu adipeux peut être soumis à d'autres traitements avant l'injection. Une augmentation sensible du tissu mou, des taux élevés de survie des greffes et une nécrose ou une calcification négligeable des greffes (des données démontrant 80% de survie et seulement 20% de nécrose sont présentées) sont le résultat de la pratique de ces procédés.
지정국: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
아프리카지역 지식재산권기구(ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
유라시아 특허청(EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
유럽 특허청(EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
아프리카 지식재산권기구(OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
공개언어: 영어 (EN)
출원언어: 영어 (EN)
또한로 출판 됨:
EP2029177US20090312746EP3064223EP3115065