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1. (WO2006138181) SELF-BUFFERING PROTEIN FORMULATIONS
국제사무국에 기록된 최신 서지정보

공개번호: WO/2006/138181 국제출원번호: PCT/US2006/022599
공개일: 28.12.2006 국제출원일: 08.06.2006
IPC:
A61K 39/395 (2006.01) ,C12P 21/08 (2006.01)
A SECTION A — 생활필수품 농업
61
위생학; 의학 또는 수의학
K
의약용, 치과용 또는 화장용 제제
39
항원 또는 항체를 함유한 의료품 제제
395
항체; 면역글로블린; 면역혈청, 예. 항림프구 혈청
C SECTION C — 화학; 야금
12
생화학; 맥주; 주정; 포도주; 식초; 미생물학; 효소학; 돌연변이 또는 유전자공학
P
발효 또는 효소를 사용하여 원하는 화학물질 또는 조성물을 합성하는 방법 또는 혼합물로부터 광학이성체를 분리하는 방법
21
펩티드 또는 단백질의 제조
08
.단클론 항체(monoclonal antibodies)
출원인:
AMGEN INC. [US/US]; M/S 28-2-C One Amgen Center Drive Thousand Oaks, CA 91320-1799, US (AllExceptUS)
GOKARN, Yatin, R. [IN/US]; US (UsOnly)
KRAS, Eva [US/US]; US (UsOnly)
REMMELE, Richard, Louis, Jr. [US/US]; US (UsOnly)
BREMS, David, N. [US/US]; US (UsOnly)
HERSHENSON, Susan, Irene [US/US]; US (UsOnly)
발명자:
GOKARN, Yatin, R.; US
KRAS, Eva; US
REMMELE, Richard, Louis, Jr.; US
BREMS, David, N.; US
HERSHENSON, Susan, Irene; US
대리인:
REINECKE, Raz; Amgen Inc. Mail Stop 28-2-C One Amgen Center Drive Thousand Oaks, CA 91320-1799, US
우선권 정보:
60/690,58214.06.2005US
발명의 명칭: (EN) SELF-BUFFERING PROTEIN FORMULATIONS
(FR) PREPARATIONS DE PROTEINES A TAMPONNAGE SPONTANE
요약서:
(EN) The invention herein described, provides, among other things, self-buffering protein formulations. Particularly, the invention provides self-buffering pharmaceutical protein formulations that are suitable for veterinary and human medical use. The self-buffering protein formulations are substantially free of other buffering agents, stably maintain pH for the extended time periods involved in the distribution and storage of pharmaceutical proteins for veterinary and human medical use. The invention further provides methods for designing, making, and using the formulation. In addition to other advantages, the formulations avoid the disadvantages associated with the buffering agents conventionally used in current formulations of proteins for pharmaceutical use. The invention in these and other respects can be productively applied to a wide variety of proteins and is particularly useful for making and using self-buffering formulations of pharmaceutical proteins for veterinary and medical use, especially, in particular, for the treatment of diseases in human subjects.
(FR) L'invention concerne, entre autres, des préparations de protéines à tamponnage spontané. L'invention concerne en particulier des préparations de protéines pharmaceutiques à tamponnage spontané qui sont appropriées pour un usage en médecine vétérinaire et humaine. Les préparations de protéines à tamponnage spontané sont sensiblement dépourvues d'autres tampons, maintiennent de manière stable le pH pour des durées prolongées impliquées dans la distribution et le stockage de protéines pharmaceutiques à usage en médecine vétérinaire et humaine. L'invention concerne également des méthodes de conception, de production et d'utilisation de la préparation. En plus d'autres avantages, les préparations évitent les désavantages associés aux tampons traditionnellement utilisés dans les préparations courantes de protéines à usage pharmaceutique. L'invention peut être appliquée de manière productive à une large variété de protéines et est particulièrement utile pour la production et l'utilisation de préparations à tamponnage spontané de protéines pharmaceutiques à usage vétérinaire et médical, notamment, en particulier, pour le traitement de maladies chez des sujets humains.
지정국: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
아프리카지역 지식재산권기구(ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
유라시아 특허청(EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
유럽 특허청(EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
아프리카 지식재산권기구(OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
공개언어: 영어 (EN)
출원언어: 영어 (EN)
또한로 출판 됨:
MXMX/a/2007/015476KR1020080031684IL188102SG162788EP1909831ZA2008/00338
JP2008543839US20080311078BRPI0611901JP2013047261CN101217979CA2610839
EA200800050JP2016053061AU2006259664AU2012272950AU2015242973AU2017202889
IN5286/CHENP/2007JP2018048196EP3351269