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1. (WO2005039644) METHOD OF TRANSFERRING SOLUBLE INTERFERON Ϝ RECEPTOR GENE AND COMPOSITION FOR PREVENTING OR TREATING ARTERIOSCLEROSIS

Pub. No.:    WO/2005/039644    International Application No.:    PCT/JP2004/016065
Publication Date: Sat May 07 01:59:59 CEST 2005 International Filing Date: Sat Oct 23 01:59:59 CEST 2004
IPC: A61K 38/00
A61K 48/00
C07K 14/715
Applicants: KURUME UNIVERSITY
学校法人久留米大学
KAI, Hisashi
甲斐 久史
IMAIZUMI, Tsutomu
今泉 勉
EGASHIRA, Kensuke
江頭 健輔
Inventors: KAI, Hisashi
甲斐 久史
IMAIZUMI, Tsutomu
今泉 勉
EGASHIRA, Kensuke
江頭 健輔
Title: METHOD OF TRANSFERRING SOLUBLE INTERFERON Ϝ RECEPTOR GENE AND COMPOSITION FOR PREVENTING OR TREATING ARTERIOSCLEROSIS
Abstract:
It is intended to provide a method of transferring soluble interferon Ϝ receptor gene by using the naked DNA method, a method of preventing/treating arteriosclerosis or restenosis following vascularization with the use of the gene transfer method, and a composition and a kit to be used in the prevention/treatment method. A composition and a kit containing soluble interferon Ϝ receptor gene (sINFgR) as the active ingredient are transferred by the naked DNA method into a skeletal muscle having been pre-treated with bupivacaine. By this gene transfer, arteriosclerosis or restenosis following vascularization can be treated.