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1. (WO2001021219) IMAGING OF DRUG ACCUMULATION AS A GUIDE TO ANTITUMOR THERAPY
국제사무국 기록상의 최신 서지정보

공개번호: WO/2001/021219 국제출원번호: PCT/US2000/025833
공개일: 29.03.2001 국제출원일: 21.09.2000
국제예비심사 청구일: 07.03.2001
IPC:
A61K 51/04 (2006.01)
A SECTION A — 생활필수품 농업
61
위생학; 의학 또는 수의학
K
의약용, 치과용 또는 화장용 제제
51
생체내 치료 또는 시험에 사용하기 위한 방사물질을 함유하는 제제
02
담체에 의하여 특징되는 것
04
유기화합물
출원인:
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer National Institute of Health 6011 Executive Boulevard, Suite 325 Rockville, MD 20852, US (AllExceptUS)
COLLINS, Jerry, M. [US/US]; US (UsOnly)
KLECKER, Raymond, N. [US/US]; US (UsOnly)
ANDERSON, Lawrence [US/US]; US (UsOnly)
발명자:
COLLINS, Jerry, M.; US
KLECKER, Raymond, N.; US
ANDERSON, Lawrence; US
대리인:
SCHNELLER, Marina; Venable P.O. Box 34385 Washington, DC 20043-9998, US
우선권 정보:
60/155,06121.09.1999US
발명의 명칭: (EN) IMAGING OF DRUG ACCUMULATION AS A GUIDE TO ANTITUMOR THERAPY
(FR) IMAGERIE D'ACCUMULATION DE MEDICAMENTS COMME GUIDE DE THERAPIE ANTITUMMORALE
요약서:
(EN) The present invention describes the use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labelled anticancer drug to a patient and imaging at least a part of the patient using Positron Emission Tomography imaging. The method is used to monitor delivery of antitumor drugs to tumors and may be used to predict the effectiveness of therapy with a particular antitumor drug or combination of antitumor drugs, to assess the effectiveness of modulators of cellular accumulation, to individualize therapy and to evaluate the effectiveness of antitumor drugs with respect to particular cancers. Particularly preferred drugs are labeled taxanes, e.g., 11C-paclitaxel and 11C-docetaxel, labeled anthracyclines, e.g., 11C-doxorubicin and 11C-epirubicin, and other radio-labeled drug, e.g. 11C-topotecan and 11C-mitoxantrone. The invention further describes antitumor drugs labeled with the radioactive label 11C and methods of preparing radio-labeled drugs.
(FR) La présente invention concerne l'utilisation de médicaments antitumoraux radio-marqués dans le traitement de tumeurs solides par un procédé consistant à administrer des médicaments anticancéreux radio-marqués à un patient et à soumettre au moins certaines parties de son corps à l'imagerie par tomographie par émission de positrons. Ce procédé est utilisé pour surveiller l'administration de médicaments antitumoraux aux tumeurs et peut être utilisé pour prévoir l'efficacité de la thérapie avec un médicament antitumoral particulier ou des médicaments antitumoraux associés, pour évaluer l'efficacité des modulateurs de l'accumulation cellulaire, et pour personnaliser la thérapie et évaluer l'efficacité des médicaments antitumoraux par rapport à des cancers particuliers. Les médicaments préférés particuliers sont les taxanes marqués, par exemple 11C-paclitaxel et 11C-docetaxel, anthracyclines marqués, par exemple, 11C-doxorubicine et 11C-epirubicine, et d'autres médicaments radio-marqués, par exemple, 11C-topotecan et 11C-mitoxantrone. En outre, cette invention concerne des médicaments antitumoraux marqués avec un marqueur radioactif 11C et des procédés de préparation de ces médicaments radio-marqués.
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지정국: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
아프리카지역 지식재산기구(ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
유라시아 특허청(EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
유럽 특허청(EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
아프리카 지식재산권기구(OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
공개언어: 영어 (EN)
출원언어: 영어 (EN)
Also published as:
US7141234AU2000075970