16:00 CET에 화요일 19.11.2019의 유지 보수 사유로 인해 몇 시간 동안 PATENTSCOPE을 사용할 수 없습니다.
국제 및 국내 특허문헌 검색
이 애플리케이션의 일부 콘텐츠는 현재 사용할 수 없습니다.
이 상황이 계속되면 다음 주소로 문의하십시오피드백 및 연락
1. (IL227105) NON-CODING IMMUNOMODULATORY DNA CONSTRUCT
유의사항: 이 문서는 자동 광학문자판독장치(OCR)로 처리된 텍스트입니다. 법률상의 용도로 사용하고자 하는 경우 PDF 버전을 사용하십시오

23

227105/3

Claims

1. A non-coding DNA construct for immunomodulation comprising at least one sequence motif N1N2CGN3N4, wherein said N'N2 and N3N4 is any combination of A, C, T, and G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine and T is deoxythymidine and wherein only at the 5’- and/or 3 ’-end of a DNA single strand of said DNA construct at least one of the terminal five nucleotides is in L-conformation.

2. The construct according to claim 1, wherein said N N is an element selected from the group comprising GT, GG, GA, AT or AA, and said N 3 N A is an element selected from the group comprising CT or TT.

3. The construct according to any one of the preceding claims, further comprising at least one G stretch comprising three consecutive deoxyguanosine directly next to the 5’ and/or 3’ end of the DNA construct.

4. The construct according to any one of the preceding claims, further comprising a G stretch comprising three consecutive deoxyguanosine located between two sequence motifs according to claim 1 or 2.

5. The construct according to any one of the preceding claims, wherein at least five nucleotides are located between two sequences motifs according to claim 1 or 2, excluding deoxyguanosine.

6. The construct according to any one of the preceding claims, wherein the DNA construct comprises at least one end with a single stranded loop.

7. The construct according to any one of the preceding claims, wherein the sequence motif N 1 N CGN 3 N 4 as defined in claim 1 is located within a single- stranded and/or a double-stranded region of the DNA sequence.

8. The construct according to any one of the preceding claims, comprising inter- and/or intramolecular base-pairs and at least one unpaired, single- stranded region.