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1. (WO2010090969) TETRAHYDROPYRAN NUCLEIC ACID ANALOGS
국제사무국에 기록된 최신 서지정보   

공개번호:    WO/2010/090969    국제출원번호:    PCT/US2010/022759
공개일: 12.08.2010 국제출원일: 01.02.2010
IPC:
C07H 19/04 (2006.01), C07H 21/00 (2006.01), A61K 31/712 (2006.01)
출원인: ISIS PHARMACEUTICALS, INC. [US/US]; 1896 Rutherford Road Carlsbad, CA 92008 (US) (For All Designated States Except US).
PRAKASH, Thazha, P. [IN/US]; (US) (For US Only).
SWAYZE, Eric, E. [US/US]; (US) (For US Only)
발명자: PRAKASH, Thazha, P.; (US).
SWAYZE, Eric, E.; (US)
대리인: RIEGER, Dale, L.; Jones Day 222 East 41st St. New York, NY 10017-6702 (US)
우선권 정보:
61/150,613 06.02.2009 US
61/259,845 10.11.2009 US
발명의 명칭: (EN) TETRAHYDROPYRAN NUCLEIC ACID ANALOGS
(FR) ANALOGUES D'ACIDE NUCLÉIQUE DE TÉTRAHYDROPYRANE
요약서: front page image
(EN)The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, novel tetrahydropyran nucleoside analogs are provided having at least one chiral substituent that are expected to be useful for enhancing one or more properties of oligomeric compounds such as nuclease resistance and/or binding affinity. In certain embodiments, the oligomeric compounds are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
(FR)La présente invention concerne des analogues de nucléosides de tétrahydropyrane, des composés oligomères obtenus à partir de ces analogues, et de procédés d'utilisation de ces composés oligomères. L'invention concerne plus particulièrement de nouveaux analogues de nucléosides de tétrahydropyrane comportant au moins un substituant chiral, nouveaux analogues dont on attend qu'ils renforcent une ou plusieurs des propriétés des composés oligomères telles que la résistances aux nucléases et/ou l'affinité pour les liaisons. Dans certains modes de réalisation, on attend de ces composés oligomères qu'ils s'hybrident à une partie d'un ARN cible, ce qui aboutirait à la perte d'une fonction normale de l'ARN cible.
지정국: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
공개언어: English (EN)
출원언어: English (EN)