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1. (WO2004002995) PHOSPHORAMIDITES FOR COUPLING OLIGONUCLEOTIDES TO [2 + 2] PHOTOREACTIVE GROUPS

Pub. No.:    WO/2004/002995    International Application No.:    PCT/IB2003/002514
Publication Date: Fri Jan 09 00:59:59 CET 2004 International Filing Date: Sat Jun 28 01:59:59 CEST 2003
IPC: C07F 9/24
C07F 9/553
C07F 9/6503
C07F 9/6506
C07H 21/00
Applicants: AMERSHAM BIOSCIENCES AB
Inventors: BRUSH, Charles, K.
ELGHANIAN, Robert
XU, Yanzheng
Title: PHOSPHORAMIDITES FOR COUPLING OLIGONUCLEOTIDES TO [2 + 2] PHOTOREACTIVE GROUPS
Abstract:
Photoreactive phosphoramidites useful for attaching photoreactive sites to nucleic acids and oligonucleotides are synthesized. The resultant nucleic acid or oligonucleotide probes incorporating the photoreactive sites are then attached to a polymer-coated support by a [2 + 2] cycloaddition to form a microarray.