WIPO - 国際・国内特許データベース検索

1.WO/2021/211792TREATMENT OF CORONAVIRUS INFECTIONS WITH AURANOFIN

WO - 21.10.2021

国際特許分類 (IPC) A61K 31/7135 出願番号 PCT/US2021/027404 出願人 GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 発明者 KUMAR, Mukesh

The present disclosure provides methods for treating viral infections, in particular treating coronavirus infections in a subject with auranofin.

2.WO/2023/073086IRON OXIDE NANOPARTICLES WITH ANTIVIRAL ACTIVITY AGAINST SARS AND MERS CORONAVIRUS

WO - 04.05.2023

国際特許分類 (IPC) A61K 9/51 出願番号 PCT/EP2022/080053 出願人 CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS 発明者 BARBER CASTAÑO, Domingo F.

Coronaviridae viruses usually cause mild respiratory disease in humans, nevertheless a new infectious disease caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since December 2019, resulting in the ongoing 2019 2021 coronavirus pandemic. The present invention discloses the use of coated iron oxide nanoparticles (IONPs) for use in the treatment and/or prevention of viral infections caused by Coronaviridae, especially those caused by respiratory syndrome-related coronaviruses such as SARS-CoV, SARS-CoV-2 and MERS-CoV. The iron oxide nanoparticles are coated with biocompatible molecules and polymers which bind to the nanoparticle core via oxygen, nitrogen and sulfur donor atoms (e.g. dextran, (3- aminopropyl)triethoxysilane or dimercaptosuccinic acid, respectively). The IONPs were found stable, non-cytotoxic in vitro and can efficiently impair virus replication, transcription and production of infectious virus. Furthermore, the IONPs are suitable for oral, intranasal or parenteral administration in combination with a pharmaceutical carrier.

3.WO/2023/073091IRON OXYHYDROXIDE NANOPARTICLES WITH ANTIVIRAL ACTIVITY AGAINST SARS AND MERS CORONAVIRUS

WO - 04.05.2023

国際特許分類 (IPC) A61K 33/26 出願番号 PCT/EP2022/080059 出願人 CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS 発明者 BARBER CASTAÑO, Domingo F.

Coronaviridae viruses usually cause mild respiratory disease in humans, nevertheless, a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since December 2019, resulting in the ongoing 2019-2021 coronavirus pandemic. The present invention discloses the use of coated iron oxyhydroxide nanoparticles (lOHNPs) for use in the treatment and/or prevention of viral infections caused by Coronaviridae, especially those caused by respiratory syndrome-related coronaviruses such as SARS-CoV and SARS-CoV-2 and MERS-CoV. The iron oxyhydroxide nanoparticles are coated with biocompatible molecules and polymers which bind to the nanoparticle core via oxygen (e.g. sorbitol and sucrose). The lOHNPs were found stable, non-cytotoxic in vitro and can efficiently impair virus replication and transcription. Furthermore, the lOHNPs are suitable for oral, intranasal or parenteral administration in combination with a pharmaceutical carrier.

4.WO/2023/079466TREATMENT OF SEQUELAE OF CORONAVIRUS INFECTIONS

WO - 11.05.2023

国際特許分類 (IPC) A61K 33/04 出願番号 PCT/IB2022/060575 出願人 SULFAGENIX, INC. 発明者 GOJON-ZORRILLA, Gabriel

The present invention features compositions and methods for treating sequelae of coronavirus infection, e.g., betacoronavirus. The present invention features a method of treating or preventing one or more sequelae of a coronavirus infection. The method includes administering to the subject a pharmaceutical composition including elemental alpha sulfur, highly polar components, and a pharmaceutically acceptable excipient in an amount and for a duration sufficient to treat or prevent the one or more sequelae of the coronavirus infection.

5.WO/2023/001814COMPOSITION FOR USE IN THE PREVENTION OF SEVERE FORMS OF VIRAL INFECTIONS DUE TO BETACORONAVIRUS

WO - 26.01.2023

国際特許分類 (IPC) A61K 31/155 出願番号 PCT/EP2022/070184 出願人 CENTRE HOSPITALIER UNIVERSITAIRE DE NIMES 発明者 CORBEAU, Pierre

The present invention concerns a composition comprising an Angiotensin receptor 1 (AT1) inhibitor and one or more other active compounds selected from the group consisting of antioxidants, caspase inhibitors, and mixtures thereof, for use as a drug in subjects in need thereof, for preventing and/or treating viral infections due to at least one betacoronavirus, in particular for preventing severe forms of viral infections due to betacoronavirus, in particular COVID-19 due to SARS-CoV-2.

6.20240091243METHODS FOR PREVENTING VIRAL INFECTION

US - 21.03.2024

国際特許分類 (IPC) A61K 31/7008 出願番号 18261592 出願人 Ameer E. HASSAN 発明者 Ameer E. HASSAN

The present disclosure relates to compounds and methods for preventing infection, symptoms, or sequelae resulting from viral infection, including influenza infection, rhinovirus infection, or betacoronavirus infection, such as human coronaviruses such as SARS coronaviruses, MERS coronaviruses, and COVID-19, including Acute Respiratory Distress Syndrome (ARDS) associated with the viral infection.

7.WO/2022/031416COMPOSITIONS AND METHODS FOR PREVENTION OF VIRAL INFECTIONS AND ASSOCIATED DISEASES

WO - 10.02.2022

国際特許分類 (IPC) A61K 33/20 出願番号 PCT/US2021/041682 出願人 MICROPURE, INC. 発明者 JAIPRAKASH, Shewale, G.

Described herein are single-phase multi-component compositions and methods for their use reducing the viral load of infectious viruses on host organisms, including but not limited to Influenza A, Rhinovirus Type 14, Adenovirus Type 5, Herpes Simplex Virus Type 1, Herpes Simplex Virus Type 2, Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2; COVID-19 virus), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), and Human coronavirus 229E. The compositions described herein comprise a combination of an oxidative compound and a buffering system. The methods of use of these compositions as antiviral agents when applied to the oral, nasal, ocular, aural, anal, and urogenital cavities are described. Data shows the compositions to be effective in reducing influenza A and the human coronaviruses. In that regard, the single-phase multi-component compositions and methods for its antiviral use disclosed herein may be offer a single, effective product to combat multiple, concurrent pandemics.

8.WO/2023/033753FOOD SUPPLEMENT WITH ANTIOXIDANT/ ANTIPROLIFERATIVE PROPERTIES

WO - 09.03.2023

国際特許分類 (IPC) A61K 36/282 出願番号 PCT/TR2021/050883 出願人 ERDEM ÜNLÜ, Gülten 発明者 ERDEM ÜNLÜ, Gülten

The present invention relates to a food supplement with antioxidant/antiproliferative properties that is used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contains artemisia annua, distilled water, colloidal silver water and Olea Europaea (olive leaf oil extract).

9.20220016053Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

US - 20.01.2022

国際特許分類 (IPC) A61K 31/137 出願番号 17357388 出願人 ZOGENIX INTERNATIONAL LIMITED 発明者 Bradley S. Galer

Provided is a method of treating a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprising: determining the patient has been infected with SARS-CoV-2; and administering to the patient a therapeutically effective dose of fenfluramine.

10.20220072036METHOD FOR INHIBITING CORONAVIRUS AND METHOD FOR TREATING DISEASE ASSOCIATED WITH CORONAVIRUS INFECTION

US - 10.03.2022

国際特許分類 (IPC) A61K 33/30 出願番号 17468293 出願人 Chung-Hsiang LIN 発明者 Bo-Lin LIN

Disclosed herein is a method for inhibiting a coronavirus, which includes administering to a subject in need thereof a retinoic acid and at least one bivalent metal ion. Also disclosed is a method for treating a disease associated with coronavirus infection, which includes administering to a subject in need thereof a retinoic acid and at least one bivalent metal ion.

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