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1.3116216SYSTEM FOR IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA) AND METHOD OF IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA)

CA - 29.10.2021

国際特許分類 (IPC) C12Q 1/70 出願番号 3116216 出願人 TELEFLEX MEDICAL INCORPORATED 発明者 BOUCHARD, MICHAEL

A system for detecting the presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a biological sample includes a sampling device, a lysing chamber, a NASBA fluidic network, and an analytical instrument. The sampling device is configured to contain a sample containing a pathogen target sequence for SARS-CoV-2. The lysing chamber is configured to be in fluid communication with the sampling device to receive the sample. The is lysing chamber is configured to lyse the sample into a lysate. The NASBA fluidic network is configured to be in fluid communication with the lysing chamber to receive the lysate. The NASBA fluidic network includes an enzyme, a forward primer, and a reverse primer for amplifying a predetermined genetic sequence in the pathogen target sequence contained within the lysate. The forward primer has the oligonucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 13, and SEQ ID NO: 17. The reverse primer has the oligonucleotide sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 14, and SEQ ID NO: 18. A molecular beacon is configured to attach to the pathogen target sequence. The beacon has the oligonucleotide sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 7, SEQ ID NO: 11, SEQ ID NO: 15, and SEQ ID NO: 19 and a fluorophore. The analytical instrument is configured to excite the beacon when the molecular beacon is attached to the pathogen target sequence to signal a presence of the pathogen target sequence.A method for detecting the presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a biological sample includes the steps of lysing the biological sample to form a lysate and generating an amplified lysate by performing a nucleic acid sequence-based (NASBA) amplification for a target nucleic acid sequence in the lysate in the presence of: a forward primer having the oligonucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 13, and SEQ ID NO: 17; a reverse primer having theoligonucleotide sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 14, and SEQ ID NO: 18; and a molecular beacon having the oligonucleotide sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 7, SEQ ID NO: 11, SEQ ID NO: 15, and SEQ ID NO: 19 and a fluorophore. The amplified lysate is exposed to an excitation source. A fluorescence of the fluorophore is detected in the amplified lysate exposed to the excitation source. The SARS-CoV-2 is determined to be present in the biological sample in response to detecting the fluorescence of the fluorophore.

2.WO/2022/056373METHODS AND RELATED ASPECTS FOR PATHOGEN DETECTION

WO - 17.03.2022

国際特許分類 (IPC) C12Q 1/34 出願番号 PCT/US2021/050056 出願人 THE JOHNS HOPKINS UNIVERSITY 発明者 ARROYO, Netzahualcoyoti

Provided herein are methods of detecting pathogen antibodies, such as a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in samples. Related devices, kits, reaction mixtures, and systems are also provided.

3.20070042350Methods and compositions for detecting sars virus and other infectious agents

US - 22.02.2007

国際特許分類 (IPC) C12Q 1/70 出願番号 10564378 出願人 LI ZE 発明者 Li Ze

This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotides sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.

4.WO/2022/020259METHODS AND DEVICES FOR DETECTING AND SEQUENCING SARS-COV-2

WO - 27.01.2022

国際特許分類 (IPC) C12Q 1/70 出願番号 PCT/US2021/042228 出願人 CENTRILLION TECHNOLOGIES, INC. 発明者 ZHOU, Wei

The present disclosure provides methods, reagents, microarray, and software products for detecting and sequencing at least part of the SARS-CoV-2 viral RNA. The microarray and methods of the present disclosure can be used to perform simultaneous detection of SARS-CoV-2 virus and other pathogens including respiratory pathogens.

5.20080254440Anti-Sars Virus Antibody, Hybridoma Producing the Antibody and Immunoassay Reagent Using the Antibody

US - 16.10.2008

国際特許分類 (IPC) C12Q 1/70 出願番号 10577310 出願人 UCHIDA YOSHIAKI 発明者 Uchida Yoshiaki

A monoclonal antibody which specifically recognizes SARS virus is provided, and an immunoassay, immunoassay reagent and immunoassay device for detecting the SARS virus using the monoclonal antibody are disclosed. The monoclonal antibody according to the present invention is a monoclonal antibody against a nucleoprotein of a corona virus causing severe acute respiratory syndrome (SARS).

6.3191423KIT FOR COLLECTING SALIVA SAMPLES

CA - 24.03.2022

国際特許分類 (IPC) C12Q 1/70 出願番号 3191423 出願人 PROCOMCURE BIOTECH GMBH 発明者 WALLERSTORFER, DANIEL

The present invention refers to a receptable for body fluids wherein inside the receptable an coronavirus deactivating composition is present in solid form, use of said receptable for the collection of saliva, a kit for collecting saliva samples comprising said receptable, the use of said kit for collecting saliva, especially saliva comprising viral RNA and a method for the detection of RNA or DNA.

7.WO/2022/178313DETECTING DISEASES IN SUBJECTS USING EXTRACELLUAR VESICLES

WO - 25.08.2022

国際特許分類 (IPC) C12Q 1/6806 出願番号 PCT/US2022/017083 出願人 THE JOHNS HOPKINS UNIVERSITY 発明者 DAS, Samarjit

Provided herein are methods of detecting a disease, condition, or disorder in a subject. In some embodiments, the methods include obtaining a set of ribonucleic acid (RNA) molecules from a population of exosomes in a biological sample obtained from the subject and detecting a plurality of target RNA molecules corresponding to a selected set of cell-specific exosomal RNA molecules in the set of RNA molecules to generate a target RNA molecular profile for the sample. In some of these embodiments, the methods also include determining that the target RNA molecular profile substantially matches a reference RNA molecular profile that correlates with the disease, condition, or disorder in a subject and/or using at least one algorithm that predicts a likelihood that the target RNA molecular profile correlates with the disease, condition, or disorder in a subject. Related biosensor devices, kits, and systems are also provided.

8.WO/2022/015731ANTERIOR NARES SWAB AND USES THEREOF

WO - 20.01.2022

国際特許分類 (IPC) A61J 1/05 出願番号 PCT/US2021/041429 出願人 PRESIDENT AND FELLOWS OF HARVARD COLLEGE 発明者 SPRINGER, Michael

The technology described herein is directed to an anterior nares swab that is automation compatible. In one aspect, the swab comprises a cap, a threaded portion, a neck, and a sample collection head. The cap can be integrally and/or monolithically formed with any one or more of the threaded portion, the neck, and the sample collection head; or can be removably coupled to any one or more of the threaded portion, the neck, and the sample collection head. In additional aspects, described herein are kits comprising said swabs and methods of using said swabs.

9.2021307409Anterior nares swab and uses thereof

AU - 20.01.2022

国際特許分類 (IPC) A61J 1/05 出願番号 2021307409 出願人 President and Fellows of Harvard College 発明者 NOVAK, Richard

10.WO/2021/202066METHOD AND SYSTEM FOR PROCESSING GENETIC DATA

WO - 07.10.2021

国際特許分類 (IPC) C12M 1/34 出願番号 PCT/US2021/021551 出願人 ALIBABA GROUP HOLDING LIMITED 発明者 GU, Fei

Processing genetic data is disclosed including inputting data, the data corresponding to source data for gene sequencing on a sample, receiving a selected data processing technique, performing, using the selected data processing technique, gene sequencing processing on the inputted data based on the pathogen genome of a predetermined pathogen to obtain a data processing result, the data processing result indicating whether the sample includes the predetermined pathogen, and presenting the data processing result.

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