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1. (WO2019042488) METHOD OF STANDARDIZED QUANTIFICATION OF COMPONENTS OF APOCRINE SWEAT
注意: このテキストは、OCR 処理によってテキスト化されたものです。法的な用途には PDF 版をご利用ください。

CLAIMS

1. A method of standardized quantification of components of apocrine sweat, characterized in that it contains the steps of:

- obtaining at least one value Λ¾ expressing the amount of at least one component of apocrine sweat in a sample of apocrine sweat and obtaining values xj, ¾, ¾ expressing the amounts of the standardization markers palmitoleyl carnitine (SMI), hydroxyoctanoyl carnitine / pimeloyl carnitine (SM2), histidine (SM3) in the same sample;

- subjecting the obtained at least one value Λ¾ expressing the amount of the at least one component of apocrine sweat to logarithmic transformation to obtain at least one loga(jc;); and

- dividing each obtained value loga(jc,) by an arithmetic mean of logarithms of the values xj, X2, X3 expressing the amounts of the standardization markers palmitoleyl carnitine (SMI), hydroxyoctanoyl carnitine / pimeloyl carnitine (SM2), histidine (SM3), to obtain the standardized values S;

as expressed by the equation:

s = logfl (*,-)

(loge ( *, ) + logfl ( x2 ) + logfl ( x3 ) ) / 3

2. The method according to Claim 1, wherein the values expressing the amounts of the at least one component of apocrine sweat are obtained by subjecting the sample of apocrine sweat to a method of analysis of liquid solutions, preferably liquid chromatography.

3. The method according to Claim 1 or 2, wherein the values expressing the amounts of the at least one component are areas under the corresponding chromatographic peaks, or values of molar, mass or volume proportions or concentrations of the components in the sample of sweat.

4. Use of the method according to any one of the preceding claims for standardization of markers in diagnostic methods from apocrine sweat samples, or in methods of identifying diagnostic markers for diagnostic methods from apocrine sweat.