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1. (WO2018142299) A THERMORESPONSIVE HYDROGEL

Pub. No.:    WO/2018/142299    International Application No.:    PCT/IB2018/050601
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Thu Feb 01 00:59:59 CET 2018
IPC: A61L 27/52
C08J 3/075
C08L 67/06
C08G 63/08
Applicants: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
Inventors: CHOONARA, Yahya Essop
KONDIAH, Pierre Pavan Demarco
KONDIAH, Pariksha Jolene
KUMAR, Pradeep
DU TOIT, Lisa Claire
MARIMUTHU, Thashree
PILLAY, Viness
Title: A THERMORESPONSIVE HYDROGEL
Abstract:
This invention relates to thermoresponsive hydrogels. Particularly, the invention relates to a thermoresponsive hydrogel comprising copolymer polyethylene glycol (PEG)-polycaprolactone (PCL)-polyethylene glycol (PEG) and polypropylene fumerate (PPF). The thermoresponsive hydrogel may further comprise a poloxamer, particularly Pluronic F-127. The invention extends to a method of manufacturing thermoresponsive hydrogels, also extends to an ink for a three dimensional (3D) printer including the thermoresponsive hydrogels. The invention further extends to a thermoresponsive hydrogel for use in the treatment of a bone injury and/or a bone defect, and/or to a method of treating a bone injury and/or a bone defect. The thermoresponsive hydrogels may include dispersed therein an active pharmaceutical ingredient (API), preferably an API falling in the Biopharmaceutics Classification System (BCS) class II, further preferably a statin type drug, most preferably simvastatin.