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1. (WO2017144648) METHOD FOR THE DIAGNOSIS OF ETOPOSIDE PRODRUG TREATABLE CANCER

Pub. No.:    WO/2017/144648    International Application No.:    PCT/EP2017/054297
Publication Date: Fri Sep 01 01:59:59 CEST 2017 International Filing Date: Sat Feb 25 00:59:59 CET 2017
IPC: C12Q 1/68
G01N 33/574
A61K 45/06
A61K 31/7048
Applicants: CELLACT PHARMA GMBH
Inventors: UTKU, Nalan
Title: METHOD FOR THE DIAGNOSIS OF ETOPOSIDE PRODRUG TREATABLE CANCER
Abstract:
The present invention pertains to a diagnostic and therapeutic method for assessing whether a patient is susceptible to the treatment of an ester-prodrug. The methods of the invention include the analysis of carboxyelesterase 2 (CES2)-expression in tumor samples as a predictive value for the assessment of treatment success with an ester-prodrug of a chemotherapeutic agent. Alternatively, the invention provides methods involving the analysis of the urinary ratio of the prodrug and the active therapeutic as another predictive value for assessing treatment susceptibility.