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1. (WO2017143220) FFA1 (GPR40) AS A THERAPEUTIC TARGET FOR NEURAL ANGIOGENESIS DISEASES OR DISORDERS

Pub. No.:    WO/2017/143220    International Application No.:    PCT/US2017/018418
Publication Date: Fri Aug 25 01:59:59 CEST 2017 International Filing Date: Sat Feb 18 00:59:59 CET 2017
IPC: A61P 3/06
A61P 3/08
G01N 33/92
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION
Inventors: SMITH, Lois
JOYAL, Jean-sebastien
Title: FFA1 (GPR40) AS A THERAPEUTIC TARGET FOR NEURAL ANGIOGENESIS DISEASES OR DISORDERS
Abstract:
The instant invention provides methods and compositions related to discovery of Free Fatty Acid Receptor 1 (FFA1) as a therapeutic target for treatment or prevention of diseases or disorders of neurons that are characterized by angiogenesis, or of vascular diseases of the eye, retinal degeneration and/or tumors more generally. Therapeutic and/or prophylactic uses and compositions of known FFA1 inhibitors, including small molecules and nucleic acid agents, are described. Methods for identification of novel FFA1 inhibitors are also provided.