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1. (WO2005047453) COMPARTMENTALIZED DEVICE FOR CELL CULTURE, CELL PROCESSING, AND SAMPLE DIALYSIS

Pub. No.:    WO/2005/047453    International Application No.:    PCT/US2004/037388
Publication Date: Fri May 27 01:59:59 CEST 2005 International Filing Date: Thu Nov 11 00:59:59 CET 2004
IPC: C12M 1/12
Applicants: WILSON WOLF MANUFACTURING CORPORATION
WILSON, John, R.
WELCH, Dan
ROBECK, Alison
PAGE, Douglas, A.
Inventors: WILSON, John, R.
WELCH, Dan
ROBECK, Alison
PAGE, Douglas, A.
Title: COMPARTMENTALIZED DEVICE FOR CELL CULTURE, CELL PROCESSING, AND SAMPLE DIALYSIS
Abstract:
A versatile compartmentalized cell culture device (10) with a selectively permeable membrane (25) separating compartments (15, 20), provides many attributes relative to traditional devices. It can be configured for high-density cell culture, co-culture, and simple dialysis while rolling or standing still. It can also be configured for continuous movement of liquid between compartments. The wide combination of attributes not found in other membrane based cell culture and bioprocessing devices includes more cell capacity, more cell secreted products capacity, higher cell and product density, increased medium capacity, minimized use of exogenous growth factors, compatibility with cell culture equipment and protocols, increased scale up efficiency, capacity tc function when rolling or standing still, capacity for perfusion without the need for pumps, and more efficient sample dialysis.