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1. (WO2003000634) VITAMIN D RECEPTOR ANTAGONISTS AND RELATED COMPOSITIONS AND METHODS OF USE

Pub. No.:    WO/2003/000634    International Application No.:    PCT/US2002/019774
Publication Date: Sat Jan 04 00:59:59 CET 2003 International Filing Date: Fri Jun 21 01:59:59 CEST 2002
IPC: C07F 5/02
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
BARSONY, Julianna
Inventors: BARSONY, Julianna
Title: VITAMIN D RECEPTOR ANTAGONISTS AND RELATED COMPOSITIONS AND METHODS OF USE
Abstract:
A compound of formula: wherein X is a C2-10 spacer, and R is a substituted or unsubstituted C6-30 aryl, a substituted or unsubstituted C5-30 heteroaryl, or where R'and R' are independently a substituted or unsubstituted aryl or a substituted or unsubstituted alkyl, wherein said compound is a vitamin D receptor (VDR) antagonist, a composition comprising same, and a method of treating a patient for a disease that can be treated prophylactically or therapeutically by administration of a VDR antagonist, which method comprises administering an effective amount of aforementioned compound or composition, whereupon the patient is treated prophylactically or therapeutically for the disease.