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. (WO1996003653) SUPERPARAMAGNETIC PARTICLES, PROCESS FOR THEIR PRODUCTION AND THEIR USE

Pub. No.:    WO/1996/003653    International Application No.:    PCT/DE1995/001028
Publication Date: Fri Feb 09 00:59:59 CET 1996 International Filing Date: Fri Jul 28 01:59:59 CEST 1995
IPC: A61K 9/50
A61K 41/00
A61K 47/48
A61K 49/18
B03C 1/01
G01N 33/543
H01F 1/36
H01F 1/44
Applicants: SILICA GEL GES.MBH ABSORPTIONSTECHNIK, APPARATEBAU
PILGRIMM, Herbert
Inventors: PILGRIMM, Herbert
Title: SUPERPARAMAGNETIC PARTICLES, PROCESS FOR THEIR PRODUCTION AND THEIR USE
Abstract:
Superparamagnetic particles consist of superparamagnetic one-domain particles and aggregates of superparamagnetic one-domain particles to whose surfaces are bound organic substances optionally having further binding sites for coupling to tissue-specific binding substances, diagnostic or pharmacologically active substances. The superparamagnetic particles consist of a mixture of small superparamagnetic one-domain particles with a particle size from 3 to 50 nanometers and stable, degradable aggregates of small superparamagnetic one-domain particles with a particle size from 10 to 1000 nanometers. They are made of iron hydroxide, iron oxide hydrate, iron oxides, iron mixed oxides or iron to the surface of which are bound mono- and/or polyhydroxylic group-containing aromatic substances, polyglycerines, amino-acid-containing substances, silicate group-containing substances among the orthosilicic acids and their condensation products and phosphate group-containing substances among the ortho- or metaphosphoric acids and their condensation products. Said substances may have further binding sites. These new particles may be used to destroy tumours, increase immunity, in magnetic drug targeting, for cell fusion, gene transfers, as contrasting agents, for in vitro diagnosis, as magnetic ion exchangers and magnetic adsorbents, if required by exposure to magnetic fields.