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1. US20130095518 - METHOD FOR PRODUCING TUMOR CELLS FROM NORMAL MAMMARY EPITHELIAL CELLS

官庁
アメリカ合衆国
出願番号 13805217
出願日 07.07.2011
公開番号 20130095518
公開日 18.04.2013
公報種別 A1
IPC
C12N 5/09
C化学;冶金
12生化学;ビール;酒精;ぶどう酒;酢;微生物学;酵素学;突然変異または遺伝子工学
N微生物または酵素;その組成物;微生物の増殖,保存,維持;突然変異または遺伝子工学;培地
5ヒト,動物または植物の細胞,例.セルライン;組織;その培養または維持;そのための培地
09腫瘍細胞
CPC
C12N 5/0693
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0693Tumour cells; Cancer cells
出願人 Akagi Tsuyoshi
EISAI R&D MANAGEMENT CO., LTD.
Sukezane Taiko
発明者 Akagi Tsuyoshi
Sukezane Taiko
優先権情報 2010-154744 07.07.2010 JP
発明の名称
(EN) METHOD FOR PRODUCING TUMOR CELLS FROM NORMAL MAMMARY EPITHELIAL CELLS
要約
(EN)

An object of the present invention is to provide a method for producing tumor cells from cells derived from normal cells without using hTERT.

    • The present invention provides a method for producing tumor cells by carrying out the following treatments (1) and (2) on normal mammary epithelial cells:
    • (1) elimination of p53 function; and
    • (2) introduction v-Src gene.