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1. IN1740/DELNP/2010 - METHOD OF MODIFYING ISOELECTRIC POINT OF ANTIBODY VIA AMINO ACID SUBSTITUTION IN CDR

官庁 インド
出願番号 1740/DELNP/2010
出願日 12.03.2010
公開番号 1740/DELNP/2010
公開日 13.08.2010
特許番号 292204
特許付与日 29.01.2018
公報種別 B
IPC
C07K 16/28
C化学;冶金
07有機化学
Kペプチド
16免疫グロブリン,例.モノクローナル抗体またはポリクローナル抗体
18動物またはヒトからの物質に対するもの
28レセプター,細胞表面抗原または細胞表面決定因子に対するもの
出願人 CHUGAI SEIYAKU KABUSHIKI KAISHA
発明者 IGAWA, TOMOYUKI
TSUNODA, HIROYUKI
TACHIBANA, TATSUHIKO
KURAMOCHI, TAICHI
発明の名称
(EN) METHOD OF MODIFYING ISOELECTRIC POINT OF ANTIBODY VIA AMINO ACID SUBSTITUTION IN CDR
要約
(EN)
The present inventors provide methods for modifying the isoelectric point of an antibody while retaining its antigen-binding activity, comprising modifying the charge of at least one exposable amino acid residue on the surface of the complementarity determining region (CDR).  The present invention also provides methods for purifying multispecific antibodies, comprising modifying isoelectric point, and methods for improving the plasma phannacokinetics of antibodies with a modified isoelectric point.  The present invention further provides antibodies with a modified isoelectric point, pharmaceutical compositions comprising the antibodies as an active ingredient, and methods for producing the antibodies and compositions.