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1. IL267546 - Method of modifying isoelectric point of antibody via amino acid substitution in CDR

官庁 イスラエル
出願番号 267546
出願日 20.06.2019
公開番号 267546
公開日 29.08.2019
公報種別 A
IPC
C07K
C化学;冶金
07有機化学
Kペプチド
CPC
A61K 39/39591
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39591Stabilisation, fragmentation
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
C07K 2317/732
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
732Antibody-dependent cellular cytotoxicity [ADCC]
C07K 2317/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
94Stability, e.g. half-life, pH, temperature or enzyme-resistance
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
出願人 CHUGAI SEIYAKU KABUSHIKI KAISHA
優先権情報 2007-250165 26.09.2007 JP
2007-256063 28.09.2007 JP
発明の名称
(EN) Method of modifying isoelectric point of antibody via amino acid substitution in CDR
(HE) שיטה לשינוי נקודה איזואלקטרית של נוגדן באמצעות התמרה של חומצה אמינית ב– CDR
要約