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1. EP2592064 - PROCESS FOR PRODUCTION OF PURIFIED CHLOROGENIC ACID-CONTAINING PHARMACEUTICAL PREPARATION

注意: このテキストは、OCR 処理によってテキスト化されたものです。法的な用途には PDF 版をご利用ください。
Claims

1. A process for producing a purified chlorogenic acid-containing preparation, comprising:

a first step of dispersing or dissolving a chlorogenic acid-containing composition as a starting material in the presence of acid clay or activated clay in a mixed solvent of 10 to 95 mass% of ethanol and water,

a second step of removing a deposit from a dispersion or solution obtained by the first step,

a third step of adjusting a concentration of chlorogenic acids and pH in a solution, which has been obtained by the second step, to from 1.5 to 10 mass% and from 2 to 4, respectively, and

a fourth step of separating the deposit formed in a concentration-adjusted solution obtained by the third step;

further comprising, after the second step and until completion of the third step, a step of adjusting a concentration of the ethanol in the solution, which has been obtained by the second step, to 5 mass% or lower.


  2. The process according to claim 1, further comprising, in the first step, a step of adjusting a pH of the dispersion or solution, which has been obtained by the first step, to from 4.6 to 7.
  3. The process according to claim 1 or 2, wherein the pH adjustment in the third step is conducted by at least one selected from a method that adds an acid to the solution with the chlorogenic acids contained therein, a method that dissolves in an acidic aqueous solution the solution with the chlorogenic acids contained therein, and a method that brings the solution with the chlorogenic acids contained therein into contact with a cation exchange resin.
  4. The process according to any one of claims 1 to 3, wherein the pH adjustment in the third step is conducted by the process that brings the solution with the chlorogenic acids contained therein into contact with the cation exchange resin.
  5. The process according to any one of claims 1 to 4, wherein a content of the chlorogenic acids in solids of the chlorogenic acid-containing composition as the starting material is from 20 to 70 mass%.