(EN) The purpose of the present invention is to provide a humanized mouse that enables the long-term survival of human hematopoietic stem cells. The present invention is a humanized rodent in which human neutrophils circulate peripherally, and is obtained by transplanting human hematopoietic cells into a human G-CSF gene knocked-in rodent that expresses human G-CSF and does not express rodent G-CSF receptor. The human G-CSF gene knocked-in rodent is an immunodeficient rodent in which a human G-CSF gene has been knocked into the G-CSF receptor gene locus and the function of the G-CSF receptor has been lost.
(ZH) 本发明的目的为提供使人造血干细胞的长期植入成为可能的人源化小鼠。本发明是向G‑CSF受体基因座中敲入人G‑CSF基因、使G‑CSF受体的功能缺损而得的免疫缺陷啮齿类动物，并且是向表达人G‑CSF且不表达啮齿类的G‑CSF受体的人G‑CSF基因敲入啮齿类动物移植人造血干细胞而得的、在外周循环有人嗜中性粒细胞的人源化啮齿类动物。
