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1. CN106519025 - Method of Modifying Isoelectric Point of Antibody Via Amino Acid Substitution in CDR

官庁 中華人民共和国
出願番号 201610952615.3
出願日 26.09.2008
公開番号 106519025
公開日 22.03.2017
公報種別 A
IPC
C07K 16/00
C化学;冶金
07有機化学
Kペプチド
16免疫グロブリン,例.モノクローナル抗体またはポリクローナル抗体
A61K 39/395
A生活必需品
61医学または獣医学;衛生学
K医薬用,歯科用又は化粧用製剤
39抗原または抗体を含有する医薬品製剤
395抗体;免疫グロブリン;免疫血清,例.抗リンパ球血清
A61P 37/02
A生活必需品
61医学または獣医学;衛生学
P化合物または医薬製剤の特殊な治療活性
37免疫またはアレルギー疾患の治療薬
02免疫調節剤
CPC
A61K 39/39591
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39591Stabilisation, fragmentation
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
C07K 2317/732
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
732Antibody-dependent cellular cytotoxicity [ADCC]
C07K 2317/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
94Stability, e.g. half-life, pH, temperature or enzyme-resistance
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
出願人 CHUGAI SEIYAKU KABUSHIKI KAISHA
発明者 IGAWA TOMOYUKI
TSUNODA HIROYUKI
TACHIBANA TATSUHIKO
KURAMOCHI TAICHI
優先権情報 2007-250165 26.09.2007 JP
2007-256063 28.09.2007 JP
発明の名称
(EN) Method of Modifying Isoelectric Point of Antibody Via Amino Acid Substitution in CDR
(ZH) 利用CDR的氨基酸取代来改变抗体等电点的方法
要約
(EN)
The present inventors provide methods for modifying the isoelectric point of an antibody while retaining its antigen-binding activity, comprising modifying the charge of at least one exposable amino acid residue on the surface of the complementarity determining region (CDR). The present invention also provides methods for purifying multispecific antibodies, comprising modifying isoelectric point, and methods for improving the plasma pharmacokinetics of antibodies, comprising modifying isoelectric point. The present invention further provides antibodies with a modified isoelectric point, pharmaceutical compositions comprising the antibodies as an active ingredient, and methods for producing the antibodies and compositions.

(ZH)
本发明人等提供:通过改变能够暴露于互补性决定区(CDR)表面的至少1个氨基酸残基的电荷,在保持抗体的抗原结合活性的同时改变抗体的等电点的方法。本发明还提供通过改变等电点来纯化多特异性抗体的方法和通过改变等电点来改善抗体的血浆中药物动力学的方法。并且,本发明提供等电点被改变的抗体、含有该抗体作为有效成分的医药组合物及其制造方法。