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1. (WO2007002163) PRODUCTION OF RECOMBINANT SELENOPROTEIN MUTANTS WITH ENHANCED CATALYTIC ACTIVITY

Pub. No.:    WO/2007/002163    International Application No.:    PCT/US2006/024093
Publication Date: Fri Jan 05 00:59:59 CET 2007 International Filing Date: Thu Jun 22 01:59:59 CEST 2006
IPC: C12N 9/00
C07K 14/00
Applicants: OHIO STATE UNIVERSITY
SAYRE, Richard
MOON, Hangsik
Inventors: SAYRE, Richard
MOON, Hangsik
Title: PRODUCTION OF RECOMBINANT SELENOPROTEIN MUTANTS WITH ENHANCED CATALYTIC ACTIVITY
Abstract:
The present invention generally relates to the production of industrially relevant quantities of selenoprotein enzymes in eukaryotic cell cultures. More specifically, the present invention generally relates to the production of such enzymes wherein one or more catalytic cysteine or serine residues are mutagenically replaced by selenocysteine.