(12) International Application Status Report

Received at International Bureau: 03 May 2013 (03.05.2013)

Information valid as of: 20 November 2014 (20.11.2014)

Report generated on: 24 June 2017 (24.06.2017)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2013/16329631 October 2013 (31.10.2013) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/US2013/03799624 April 2013 (24.04.2013) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
61/637,631 (US)24 April 2012 (24.04.2012) Priority document received (in compliance with PCT Rule 17.1)
61/779,533 (US)13 March 2013 (13.03.2013) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C12N 5/07 (2010.01); C12N 5/02 (2006.01); A61K 48/00 (2006.01)

(71) Applicant(s):
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street Boston, Massachusetts 02115 (US) (for all designated states)
RIKEN [JP/JP]; 2-1, Hirosawa Wako-Shi Saitama, 351-0198 (JP) (for all designated states)
TOKYO WOMEN'S MEDICAL UNIVERSITY [JP/JP]; 8-1, Kawada-cho Shinjuku-ku Tokyo, 162-8666 (JP) (for all designated states)

(72) Inventor(s):
VACANTI, Charles A.; 355 Pond Street Uxbridge, Massachusetts 01569 (US)
VACANTI, Martin P.; 1441 Monticello Dr.#2 Manhattan, Kansas 66502 (US)
KOJIMA, Koji; 50 Longwood Avenue #414 Brookline, Massachusetts 02446 (US)
OBOKATA, Haruko; c/o RIKEN 2-1, Hirosawa Wako-shi Saitama, 351-0198 (JP)
WAKAYAMA, Teruhiko; c/o RIKEN 2-1, Hirosawa Wako-shi Saitama, 351-0198 (JP)
SASAI, Yoshiki; c/o RIKEN 2-1, Hirosawa Wako-shi Saitama, 351-0198 (JP)
YAMATO, Masayuki; c/o Tokyo Women's Medical University 8-1, Kawada-cho Shinjuku-ku Tokyo, 162-8666 (JP)

(74) Agent(s):
RESNICK, David; Nixon Peabody LLP 100 Summer Street Boston, Massachusetts 02110-2131 (US)

(54) Title (EN): GENERATING PLURIPOTENT CELLS DE NOVO
(54) Title (FR): GÉNÉRATION <i>DE NOVO</i> DE CELLULES PLURIPOTENTES

(57) Abstract:
(EN): The technology described herein relates to methods, assays, and compositions relating to causing a cell to assume a more pluripotent state, e.g. without introducing foreign genetic material.
(FR): La technologie décrite ici concerne des procédés, des dosages et des compositions destinés à faire qu'une cellule devienne davantage pluripotente, par exemple sans introduction de matériel génétique étranger.

International search report:
Received at International Bureau: 04 September 2013 (04.09.2013) [RU]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM