(12) International Application Status Report

Received at International Bureau: 05 October 2015 (05.10.2015)

Information valid as of: 16 June 2017 (16.06.2017)

Report generated on: 24 June 2018 (24.06.2018)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2016/04641931 March 2016 (31.03.2016) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/EP2015/07229228 September 2015 (28.09.2015) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
14186723.4 (EP)28 September 2014 (28.09.2014) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 31/683 (2006.01); A61K 31/7034 (2006.01); C07H 15/20 (2006.01); C07F 9/10 (2006.01); A61P 35/00 (2006.01); A61P 33/02 (2006.01); A61K 35/15 (2015.01); A61P 33/00 (2006.01); A61P 31/00 (2006.01)

(71) Applicant(s):
BERNHARD-NOCHT-INSTITUT FÜR TROPENMEDIZIN [DE/DE]; Bernhard-Nocht-Straße 74 20359 Hamburg (DE) (for all designated states)
FORSCHUNGSZENTRUM BORSTEL [DE/DE]; Leibniz-institut Für Medizin Und Biowissenschaften Parkallee 1-40 23765 Borstel (DE) (for all designated states)

(72) Inventor(s):
LOTTER, Hannelore; Kleine Koppel 2 21521 Wohltorf (DE)
BERNIN, Hannah; Parsifalweg 23 G 22559 Hamburg (DE)
TANNICH, Egbert; Rönkrei 36 22399 Hamburg (DE)
GONZALEZ-ROLDAN, Nestor; Lehwisch 16 23795 Negernbötel (DE)
FUJIMOTO, Yukari; 3-1-1506 Shinkawasaki Saiwai-ku Kawasaki, Kanagawa 212-0032 (JP)
FUKASE, Koichi; 2-3-1-311 Hotarugaike-nakamichi Toyonaka, Osaka 560-0033 (JP)

(74) Agent(s):
UEXKÜLL & STOLBERG; Beselerstr. 4 D-22607 Hamburg (DE)

(54) Title (EN): NEW IMMUNOSTIMULATORY COMPOUNDS
(54) Title (FR): NOUVEAUX COMPOSÉS IMMUNOSTIMULANTS

(57) Abstract:
(EN): The present invention relates to novel immunostimulatory molecules which are derived from the intestinal protozoan Entamoeba histolytica.The compounds have been found to be useful for enhancing and/or inducing an immune response in a subject in need thereof. Specifically, the compounds have been found to be useful for the treatment of cancer diseases, such as breast cancer, and parasitic diseases, such as leishmaniasis. The invention also provides pharmaceutical compositions comprising the novel compounds.
(FR): La présente invention concerne de nouvelles molécules immunostimulantes qui dérivent du protozoaire intestinal Entamoeba histolytica.Les composés se sont avérés utiles pour renforcer et/ou induire une réponse immunitaire chez un sujet en ayant besoin. Spécifiquement, les composés se sont avérés utiles pour le traitement de maladies cancéreuses, telles que le cancer du sein, et de maladies parasitaires, telles que la leishmaniose. La présente invention concerne également des compositions pharmaceutiques comprenant les nouveaux composés.

International search report:
Received at International Bureau: 26 October 2015 (26.10.2015) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM