OMPI – Recherche dans les collections de brevets nationales et internationales

1.1995000029N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS

KE - 21.04.1998

CIB C07D 215/44 N° de demande 1995000029 Déposant F.HOFFMANN-LA ROCHE AG; Inventeur LEUPIN, Werner;

Disclosed are N,N'-bis(quinolin-4-yl)-diamine derivatives of general formula (I) wherein R1 signifies halogen or trifluoromethyl, R2 signifies hydrogen or halogen, A signifies cyclohexane-1,3-diyl, 2-methyl-cyclohexane-1,3-diyl, cyclohexane-1,4-diyl, dicyclohexylmethane-4,4'-diyl, cyclopentane-1,3-diyl, phenylene-1,4, phenylene-1,3, phenylene-1,2, ethene-1,2-diyl or ethyne-1,2-diyl and n and m can be the same or different and signify 0, 1 or 2, as well as their pharmaceutically acceptable salts. These products are useful as agents for preventing malaria and for treating it, especially where the pathogens are resistant to chloroquine.

2.1996000187DISTRIBUTION DEVICE FOR THE TELECOMMUNICATION AND DATA TECHNIQUE

KE - 18.08.1999

CIB H04Q 1/14 N° de demande 1996000187 Déposant KRONE AKTIENGESELLSCHAFT Inventeur Ingo DOHNKE, Gunter HEGNER & Gerd RICHTER

The present invention relates to a distribution block for the telecommunity and data technique, in particular for the main distribution frame of telephone and data lines, comprising insulation displacement contact elements for the connection of the subscriber cables as well as of the exchange office cables, one-piece contact springs disposed in the interior of the modular- design distribution block, a mounting bracket , in particular for receiving distribution blocks comprising a U-shaped tub, a device for guiding cables being rotatably moved in a partial section, and with cable guide portions.

3.1999000296THE PROCESSING OF COCHORUS OLITORIUS EXTRACTS

KE - 30.07.2004

CIB A61K 35/78 N° de demande 1999000296 Déposant PETER STEPHEN ODHIAMBO AGULO Inventeur

The invention relates to a process of preserving the corchirus oliterus in such a state that it remains stable even after along duration of storage.This is achieved the blanched , preserved and dried plant material is ground to powder -crude tiligel powder.The stabilized Tiligel can be dried by spray drying to give the purified Tiligel Powder . The Tiligel powder when added to hot water with stiring forms a mucilagenous gel, which is then filtered and to it added a preservative and a antioxidant .

4.1999000288PROCESS FOR PRODUCING STOCK CUBES

KE - 30.04.2005

CIB A23P 1/12 N° de demande 1999000288 Déposant BESTFOODS LTD Inventeur FELIX HEPFER .

The invention relates to a process for producing stock cubes by mixing the customary constituents comprising salt , fat extractand if appropriate, water and also other customery addidives,by continous addition of the constituents one after the other in an extruder ,an amount of fat which is reduced in comparison with customery formullation of 4-30%, in particular 5-25%, based on the total mixture , being used,the mixture continously processed inthe extruder being extruded through a shaping die to a density of 1.0-2.0g/cm3, preferably 1.2-1.7g/cm3,and the extrudate being portioned to the individual piece which are packaged.

5.2005000388FUNGICIDAL COMPOSITION COMPRISING A PYRIDYLETHYLBENZAMIDE DERIVATIVE AND A COMPOUND CAPABLE OF INHIBITING THE SPORES GERMINATION OR MYCELIUM GROWTH BY ACTING ON DIFFERENT METABOLIC ROUTES

KE - 30.06.2009

CIB A01N 43/40 N° de demande 2005000388 Déposant BAYER CROPSCIENCE SA Inventeur GROSJEAN-COURNOYER, Marie-Claire;

A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and a compound capable of inhibiting the spores germination or mycelium growth by acting on different metabolic routes (b) in a (a) / (b) weight ratio of from 0.01 to 20. A composition further comprising an additional fungicidal compound. A method for preventively or curatively combating the phytopathogenic fungi of crops by using this composition.

6.2005000452DEVELOPMENT OF A VAGINAL SPERMICIDE AND MICROBICIDE TO PREVENT PREGNANCY AND TRANSMISSIONN OF HIV/AIDS (PCT/KE2006/000015)

KE - 30.06.2006

CIB A61K 9/06 N° de demande 2005000452 Déposant DR MWETHERA PETER GICHUHI Inventeur

A safe and easy to use substance that would reliably protect the vagina from HIV infection and prevent pregnancy would be a great empowerment to women. Historical evidence from the Mediterranean region shows that lemon juice was once widely used as a contraceptive in the vagina. In addition, it is reported that Casanova advocated the use of half a lemon as a contraceptive which many people believe led to today's cervical caps and diaphragms. We have carried out preliminary studies which show that administrattion of neat lemon juice into the baboon vagina lowers the vaginal pH with the resultant adverse effects on ejaculated baboon sperm. Inorder to evaluate the safety, efficacy and acceptability of lemonn juice as a conntraceptive (Spermicide) and/or Viruside to HIV, we have developed a vaginal gel which incorporates neat lemon juice. We shall examine the effect of this vaginal gel on HIV infectionn and fertility in preclinical studies using baboon model and in clinical studies in human.

7.2008000737HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES.

KE - 28.02.2009

CIB C07C 205/45 N° de demande 2008000737 Déposant SYNGENTA PARTICIPATIONS AG Inventeur TOBLER, Hans

The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by the groups R6, R7 and R8; R1 is hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, CH2C=CR9, CH2CR10=CHR11, CH=C=CH2 or COR12; R2 and R3 are each, independently, hydrogen, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl or C1-4 haloalkoxy; R4 and R5 are each independently selected from halo, cyano and nitro; or one of R4 and R5 is hydrogen and the other is selected from halo, cyano and nitro; R6, R7 and R8 are each, independently, hydrogen, halo, cyano, nitro, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy(C1-4)alkyl, C1-4 haloalkoxy(C1-4)alkyl or C1-4 haloalkoxy, provided that at least one of R6, R7 and R8 is not hydrogen; R9, R10 and R11 are each, independently, hydrogen, halo, C1-4 alkyl, C1-4 haloalkyl or C1-4 alkoxy(C1-4)alkyl; and R12 is hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-4 alkoxy(C1-4 )alkyl, C1-4 alkylthio(C1-4)- alkyl, C1-4 alkoxy or aryl; to the preparation of these compounds, to novel intermediates used in the preparation of these compounds, to agrochemical compositions which comprise at least one of the novel compounds as active ingredient, to the preparation of the compositions mentioned and to the use of the active ingredients or compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.

8.1993000077IMPROVEMENT RELATED TO TEA PROCESSING

KE - 31.08.2000

CIB A23F 3/36 N° de demande 1993000077 Déposant TEA PROJECTS OVERSEAS LIMITED Inventeur DAVID JOHN MILLIN

A process for preparing a decaffeinated tea product comprises subjecting green, partly processed or black leaf to solvent extraction by contacting the said leaf one or more times with an organic solvent medium, wherein the organic solvent medium comprises ethyl acetate and is rich in non-caffeine tea products by (i) being previously subjected to contact with decaffeinate tea or (ii) being previously subjected to contact with non-decaffeinated tea followed by selective removal of organic solvent medium, the organic solvent medium is regenerated for further use by liquid/liquid extraction of the liquid phase resulting from the extraction with water at a pH of 2.

9.1996000047PAINT DISPENSING SYSTEM

KE - 25.05.1999

CIB B65D 35/28 N° de demande 1996000047 Déposant THE TESTOR CORPORATION; Inventeur MORRISON, Adam, P.;

A paint pouch assembly includes a pair of facing sidewalls (12, 14) sealed along their periphery. A fitting (30) has a fluid passage that terminates in an inlet (44) disposed within a cavity of the pouch and the inlet faces outwardly toward one of the sidewalls. By depressing the sidewall over the opening, fluid can be regulated through the fitting. The collapsible pouch may be used in a number of different applications. It may be incorporated into a dispensing apparatus (B) that uses a hinged presser member (108) to urge paint through the fitting and out through a pivoting head (130) received on the opposite end. Removable attachments (138, 140, 142, 144,) can be secured to the head to provide for a fine marker, foam brush, etc. Alternatively, the collapsible pouch can be used with a well structure that is secured to an artist's palette (Fig. 22).

10.1999000118HYDRAZINE DERIVATIVES

KE - 30.01.2001

CIB A61K 31/18 N° de demande 1999000118 Déposant F.HOFFMANN-LA ROCHE AG; Inventeur BROADHURST, Michael, John; JOHNSON, William, Henry; WALTER, Daryl, Simon

Hydrazine derivatives of formula (I) wherein Y signifies CO or SO₂; R¹ signifies lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R² signifies lower alkyl, halo-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl or aryl when Y signifies SO₂ and signifies lower alkyl, halo-lower alkyl, lower alkoxy, lower alkoxycarbonyl, acyl, lower cycloalkyl, aryl, aryl-lower alkyl, aryl-lower alkoxy or NR⁵R?6?? when Y signifies CO; and R³ signifies hydrogen, lower alkyl optionally substituted by cyano, amino, hydroxy, lower alkoxy, lower alkoxycarbonly, heterocyclyl or heterocyclylcarbonyl, lower alkenyl, lower alkynyl, lower cycloalkyl, lower cycloalkyl- lower alkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl or heterocyclyl; or R² and R³ together form the residue of a 5-, 6- or 7- membered cyclic amide, cyclic imide, cyclic sulphonamide or cyclic urethane group; R⁴ signifies lower alkyl, hydroxy-lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkly-lower alkyl or a grouping of the formula X-aryl, X-heteroaryl or -(CH₂)_1-2-CH=CR⁷R⁸; X signifies a spacer group; R⁵ and R⁶ each individually signify hydrogen, lower alkyl or aryl-lower alkyl; and R⁷ and R⁸ together represent a lower alkylene group in which one methylene group is optionally replaced by a hetero atom; and their pharmaceutically acceptable salts inhibit not only the release of tumour necrosis factor (TNF-$g(a)) and transforming growth factor (TGF-$g(a)) from cells, but also keratinocyte proliferation. They are useful as medicaments, especially for the treatment of inflammation, fever, haemorrhage, sepsis, rheumatoid arthritis, osteoarthritis, multiple sclerosis or psoriasis.

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