WO/2016/063269 USE OF ANTAGONISTS TO THE NUCLEAR STEROID RECEPTOR ALONE OR IN COMBINATION AS DIRECT ANTIVIRAL AGENTS TO INHIBIT ALPHAVIRUS, TOGAVIRIDAE, ARENAVIRIDAE, FILOVIRIDAE, BUNYAVIRIDAE, FLAVIVIRIDAE AND RHABDOVIRIDAE||WO||28.04.2016|
||PCT/IE2015/000016||PRENDERGAST, Patrick T. ||PRENDERGAST, Patrick T. |
The present invention is directed to therapeutic use of antagonists of the mineralocorticoid / aldosterone receptor for their previously unappreciated, prophylactic and therapeutic properties in preventing damage to the endothelial barrier that causes loss of vascular integrity resultant from filoviral infection of a patient and the effect of the Ebola viral coat glycoproteins GP1 / 2 attaching to the aldosterone receptor and causing the loss of endothelial cell attachment leading to characteristic haemorrhaging which results in hypovolemic shock to the patient. The invention also relates to compositions that comprise antagonist of the mineralocorticoid / aldosterone receptor and an excipient.
WO/2016/059625 SUPPORT APPARATUS FOR A SUBJECT AND A METHOD FOR SUPPORTING A SUBJECT IN A SUBSTANTIALLY INVERTED STATE||WO||21.04.2016|
||PCT/IE2015/000015||MIPINEYE LIMITED ||CUNNINGHAM, Brian Patrick |
Apparatus (60) for supporting a subject (2) in an inverted state comprises a ground engaging plinth (8) and a support platform (12) pivotally coupled to the plinth (8) about a first pivot axis (15) so that the support platform (12) is pivotal between a first state with a subject (2) in a supine state on the support platform (12) and a second state with the subject (2) inverted on the support platform (12). The subject is supported in the inverted state on the support platform (12) by shoulder engaging elements (24), and is secured to the support platform (12) by a torso strap (35). A foot engageable element (77) connected to a weight carrying bar (84) through connecting members (79,82) extending through an elongated slot (80) in the support platform (12) allows leg and abdominal muscles to be exercised by urging the foot engageable element (77) in the direction of the arrow A against weights (85) carried on the weight carrying bar (84). A carrier element (81) slideable on a guide bar (83) guides the foot engageable element (77). Handgrips (86) are connected by steel cables (87) around pulleys (88, 89, 90, 91) to the weight carrying bar (84) for facilitating exercising of arm, shoulder, chest and back muscles.
WO/2016/059624 COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES||WO||21.04.2016|
||PCT/IE2015/000014||PRENDERGAST, Patrick T. ||PRENDERGAST, Patrick T. |
A method for treating or preventing laminitis is provided comprising administering to an ungulate a therapeutically or prophylactically effective amount of a camelid protease inhibitor. Typically the ungulate is a horse and the camelid protease inhibitor is an inhibitor of equine metalloproteinases and equine serine proteases. The inhibitor may be isolated from blood from healthy camelid or may be generated by inoculating camelid with purified equine metalloproteinase enzymes and serine proteases or with snake venom metalloproteinases, such as those obtained from Bothrops jararaca. The inhibitor may a homodimer antibody or an antigen binding fragment of same. Also provided are compositions comprising such camelid protease inhibitors.
WO/2016/059623 A SECURE BICYCLE PARKING SYSTEM||WO||21.04.2016|
||PCT/IE2015/000013||CYC-LOK LIMITED ||MURPHY, Anna-Marie, Louise |
A secure bicycle parking system (1) comprises a plurality of lockers (3) comprising a base (8), a top wall (10) and side walls (9) which extend between the base (8) and the top wall (10) and converge towards an apex (18) from an open mouth (14). A door (15) closes the open mouth (14), and in turn a hollow interior region (12) within which a bicycle is located. Solenoid operated bolts (16) secure the door (15) in a closed state. The solenoid operated bolts (16) are operated by a microprocessor (30) for opening and closing the door (15) in response to validation of an identity code read by a card reader (31 ) in a control tower 5 from a card having the identity code imbedded in a machine readable configuration for operating the solenoid operated bolt (16) of one of the lockers (3) to release the door (15) thereof in order to provide access to the locker (3) for locating or removing a bicycle therefrom.
WO/2016/024258 A TENT AND A METHOD FOR HEAT INSULATING A TENT||WO||18.02.2016|
||PCT/IE2015/000011||THERMO TENTS LIMITED ||O'SULLIVAN, Derek Daniel |
A tent (1 ) comprises a flysheet (4) supported on a plurality of ground engaging tent poles (7), each of which terminate in respective opposite ground engaging ends (8). A heat insulated enclosure (2) is suspended within the flysheet (4) from the ground engaging tent poles (7) by suspension straps (24). The heat insulated enclosure (2) comprises a heat insulated groundsheet (17), a heat insulated peripheral side wall (19) extending upwardly from the heat insulated groundsheet (17) to a heat insulated ridge element (20), all of which include spaced apart inner and outer sheets (25, 26) of fabric material with a heat insulating material (27) such as cellucotton material of thickness typically in the range of 15mm to 40mm sandwiched between the inner and outer sheets (25, 26). The heat insulated enclosure defines an open mouth (21) which is closed by a heat insulated closure sheet (22), and the heat insulated enclosure (2) communicates with a day compartment (10) located forwardly of the heat insulated enclosure (2) within the flysheet (4).
WO/2016/024259 A DRUM SOUND SIMULATING APPARATUS AND A FOOT ACTUATED STRIKER APPARATUS||WO||18.02.2016|
||PCT/IE2015/000012||CONUNDRUM MUSIC LIMITED ||MALONE, Declan William |
A foot actuated striker apparatus comprises a striker element pivotally carried on a mounting member extending upwardly from the base. The striker element comprises a carrier arm carrying a striker head. The carrier arm is pivotally mounted on the mounting member. A linkage mechanism couples the striker element to a foot pedal, so that when the foot pedal is depressed downwardly, the striker head is urged to strike an object. A sensor housing is located on the carrier arm and carries a piezoelectric sensor sandwiched between first and second vibration damping pads. The sensor detects a strike of the striker head against the object, while the first and second vibration damping pads damp put secondary vibrations in the carrier arm. The sensor produces an electrical signal indicative of the strike, applied to a drum sound simulator to produce a selectable drum sound, and which is substantially noise free.
WO/2016/020907 A FURNITURE ITEM||WO||11.02.2016|
||PCT/IE2015/000010||ROGERS, Justin Patrick ||ROGERS, Justin Patrick |
A modular furniture item (1) formed from modular panels (2) structurally and electrically connected at dual purpose structural cum electrical male connectors (10) and female connectors (11) in which a base panel (3), upright or vertical support panels (4,5,6), a top bulkhead panel (7) and a shelf panel (9) can be connected by the male connectors (10) and female connectors (11) to form a structurally and electrically interconnected shelving system (1).
WO/2016/009418 A HEATING SYSTEM AND A METHOD FOR CONTROLLING A HEATING SYSTEM||WO||21.01.2016|
||PCT/IE2015/000009||KEANE, Bernard Michael ||KEANE, Bernard Michael |
A heating system (1) comprises a heat exchange vessel (3) having a first heat exchange coil (9) and a second heat exchange coil (10) located therein. Primary heat exchange water is heated in either or both an oil fired boiler (12) and a back boiler (14) and is circulated between the respective boilers (12) and (14) on the one hand and the heat exchange vessel (3) on the other hand. Heated primary heat exchange water is delivered from the boilers (12,14) through first inlet ports (25) and returned to the boilers (12,14) through first outlet ports (26) substantially midway along the heat exchange vessel (3). A space heating heat exchange circuit (15) is supplied with primary heat exchange water from the heat exchange vessel (3) through a second outlet port (38) and a second inlet port (39). A solar panel (22) supplies heated secondary heat exchange water to the first heat exchange coil (9), while domestic hot water is supplied through the second heat exchange coil (10). A heat dump heat exchanger (24) cools the primary heat exchange water on the primary heat exchange water in the heat exchange vessel (3) exceeding a predefined upper temperature.
WO/2016/009417 A SADDLE TREE AND A METHOD FOR LIMITING UPWARD TRAVEL OF A SEAT FORMING ELEMENT RELATIVE TO A BACK ENGAGING ELEMENT OF THE SADDLE TREE||WO||21.01.2016|
||PCT/IE2015/000008||LAM TECHNOLOGIES LIMITED ||LACEY, William, Vincent |
A saddle tree comprising a back engaging element (3) for engaging and sitting on the back of an animal and a seat forming element (4) resiliency coupled to the back engaging element (3) adjacent the pommel (5) by a pair of resilient mounting members (8). A limit strap (17) is anchored to the back engaging element (3) and is adjustably coupled to the seat forming element (4) by a ratchet mechanism (20). The limit strap (17) terminates in a grippable element (32) which is releasably grippable by the ratchet mechanism (20). By urging the grippable element (32) in the direction of the arrow A through the ratchet mechanism (20), the limit of upward travel of the seat forming element (4) relative to the back engaging element (3) is reduced, thereby effectively hardening the saddle.
WO/2016/001907 MOGROSIDE IV AND MOGROSIDE V AS AGONIST/STIMULATOR/UN-BLOCKING AGENT FOR TOLL-LIKE RECEPTOR 4 AND ADJUVANT FOR USE IN HUMAN/ANIMAL VACCINE AND TO STIMULATE IMMUNITY AGAINST DISEASE AGENTS.||WO||07.01.2016|
||PCT/IE2015/000007||PRENDERGAST, Patrick, T. ||PRENDERGAST, Patrick, T. |
This patent presents evidence that Mogroside IV.Mogroside V and combinations thereof act as a Toll -Like Receptor -4 agonist and immune stimulant that can be utilized for both therapeutic vaccine design in cancer and for other pathogenic agents. Therapy with Mogroside IV. Mogroside V and combinations thereof are also presented to created immune clearance of a viral infection.