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1. WO2020194066 - SYSTÈMES ET PROCÉDÉS POUR MACHINES OLIGOMÈRES BISTABLES

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CLAIMS

What is claimed is:

1. An oligomeric machine component configured to exhibit conformational bistability, comprising:

a first oligomeric module having a first end and a second end;

a second oligomeric module having a first end and a second end,

wherein the first end of the first oligomeric module is joined to the first end of the

second oligomeric module; and

wherein a relative orientation of the first oligomeric module and the second

oligomeric module changes from a first orientation to a second orientation in response to an applied stimulus.

2. The oligomeric machine component according to claim 1, wherein the oligomeric machine component repeatedly fluctuates between the first orientation and second orientation in response to the applied stimulus.

3. The oligomeric machine component according to claim 1, wherein an applied stimulus is a first stimulus and the relative orientation of the first oligomeric module and the second oligomeric module changes from the second orientation to the first orientation upon application of an additional stimulus and/or cessation of the first stimulus.

4. The oligomeric machine component according to claim 1, wherein the applied stimulus is any one or more of a change in temperature, a set temperature, an electric field, a magnetic field, a change in pH, an applied force of at least 10 picoNewtons, a prescribed amount of energy, and/or a change in ionic strength.

5. The oligomeric machine component according to claim 1, further comprising at least one bending or hinge location at a position of co-joinder between the first and second oligomeric modules.

6. The oligomeric machine component according to claim 5, wherein the at least one bending or hinge location comprises a third oligomeric module having a flexibility substantially greater than the flexibility of each of the first and second oligomeric modules.

7. The oligomeric machine component according to claim 6, wherein the applied stimulus causes the third oligomeric module to flex while the first and second oligomeric modules remains substantially un-flexed.

8. The oligomeric machine component according to claim 1, further comprising at least one extender formed of a material different from the first and second oligomeric modules and having a flexibility less than the flexibility of the oligomeric modules.

9. The oligomeric machine component according to claim 1, wherein each oligomeric segment has a length from 0.5 nm up to 15 nm.

10. The oligomeric machine component according to claim 1, wherein at least one oligomeric module comprises at least 15 repeating units of stereo-regular or stereo-irregular Poly(N-isopropylacrylamide).

11. The oligomeric machine component according to claim 1, wherein at least one oligomeric module comprises at least 15 repeating units of stereo-regular or stereo-irregular Poly(N-isopropylmethacrylamide).

12. The oligomeric machine component according to claim 1, wherein the first oligomeric module comprises at least 5 repeating units of Poly(N-isopropylacrylamide) in the stereo-regular or the stereo- irregular form, the second oligomeric module does not comprise Poly(N-isopropylacrylamide) and has a persistence length of at least 0.5 nm, and at least a one-third portion of the first oligomeric module does not flex more than 50% along a length of the at least one-third portion.

13. The oligomeric machine component according to claim 1, wherein at least one of the first or second oligomeric modules comprises an isotactic block.

14. The oligomeric machine component according to claim 1, wherein at least one of the first or second oligomeric modules comprises an atactic block.

15. The oligomeric machine component according to claim 1, wherein at least one of the first or second oligomeric modules comprises a syndiotactic block.

16. The oligomeric machine component according to claim 1, wherein the first and second oligomeric modules are selected and joined such that the oligomeric machine component is configured to have a conformational transitional temperature within 250 K to 400 K.

17. The oligomeric machine component according to claim 1, wherein the first and second oligomeric modules comprise a common monomeric unit.

18. The oligomeric machine component according to claim 1, further comprising a rigid molecular structure such as a nanotube or DNA.

19. The oligomeric machine component according to claim 1, wherein the joined first and second oligomeric modules comprises an isotactic Poly(N-isopropylacrylamide) block and an atactic Poly(N-isopropylacrylamide) block.

20. The oligomeric machine component according to claim 1, wherein the joined first and second oligomeric modules comprises a Poly(N-isopropylmethacrylamide) block between two Poly(2-Isopropyl-N-methylacrylamide) blocks.

21. An oligomeric machine, comprising:

a synthetic material including a first oligomeric module and a second oligomeric module joined to the first oligomeric module to form an oligomeric chain;

at least one bending or hinge location at a position of co-joinder between the first oligomeric module and the second oligomeric module, the bending or hinge location permitting relative flexure between the first oligomeric module and the second oligomeric module;

at least one electric generating element;

a substrate configured relative to the at least one electric generating element and the oligomeric chain such that the relative flexure between the first oligomeric module and the second oligomeric module results in mechanical interaction between at least the second oligomeric module of the oligomeric chain and the at least one electric generating element; and

wherein the oligomeric chain is formed such that in response to a stimulus, the relative flexure occurs between the first oligomeric module and the second oligomeric module in a manner causing the mechanical interaction between the second oligomeric module and the electric generating element, and wherein the mechanical interaction produces a change in electrical voltage associated with the at least one electric generating element.

22. The oligomeric machine according to claim 21, further comprising at least one light-absorbing element attached to the oligomeric chain at the at least one bending or hinge location wherein the oligomeric chain with light-absorbing element is formed such that in response to a prescribed amount of light energy applied to the light-absorbing element, the relative flexure occurs between the first oligomeric module and the second oligomeric module in a manner causing the mechanical interaction between the second oligomeric module and the at least one electric generating element to produce a change in electrical voltage associated with the at least one electric generating element.

23. The oligomeric machine according to claim 21, further comprising at least one chemically specific site disposed at the at least one bending or hinge location of the oligomeric chain for selective binding of a detectable molecule wherein the oligomeric chain with the chemically specific site is formed such that in response to binding of a detectible molecule, the relative flexure occurs between the first oligomeric module and the second oligomeric module in a manner causing the mechanical interaction between the second oligomeric module and the at least one electric generating element to produce a change in electrical voltage associated with the at least one electric generating element.

24. The oligomeric machine according to claim 21, wherein the electric generating element includes at least one of a piezoelectric element, nano-particle, nano-wire, or nano-layer.

25. The oligomeric machine according to claim 21, wherein the oligomeric chain comprises a Poly(N-isopropylmethacrylamide) block between two Poly(2-Isopropyl-N-methylacrylamide) blocks.

26. An oligomeric drug delivery machine, comprising:

a first oligomeric module;

a second oligomeric module connected to the first oligomeric module at a bend or hinge location to form an oligomeric chain;

a therapeutic agent captured between the first oligomeric module and the second

oligomeric module;

wherein the oligomeric chain is configured such that upon application of energy

thereto, relative movement occurs between the first oligomeric module and the second

oligomeric module such that the captured therapeutic agent is released.

27. The oligomeric drug delivery machine according to claim 26, further comprising a targeting agent configured to facilitate delivery of the therapeutic agent in a targeted manner to at least one organ in a mammalian body.

28. The oligomeric drug delivery machine according to claim 27, wherein the targeting agent comprises an antibody.

29. The oligomeric drug delivery machine according to claim 26, wherein the therapeutic agent is captured between the first oligomeric module and the second oligomeric module by a non-covalent bond.

30. The oligomeric drug delivery machine according to claim 26, wherein the therapeutic agent is captured between the first oligomeric module and the second oligomeric module by a chemical bond.

31. The oligomeric drug delivery machine according to claim 30, wherein the chemical bond is a hydrolysable bond, and wherein in response to the relative flexure occurring between the first oligomeric module and the second oligomeric module, the hydrolysable bond is exposed to a solvent, which is configured to break the hydrolysable bond and release the captured therapeutic agent.

32. The oligomeric drug delivery machine according to claim 26, wherein the therapeutic agent is encapsulated within an encapsulation structure arranged for engagement by the oligomeric chain such that application of energy to the oligomeric chain induces the relative flexure between the first oligomeric module and the second oligomeric module in a manner causing rupture of the encapsulation structure and release of the therapeutic agent.

33. The oligomeric drug delivery machine according to claim 26, wherein the oligomeric chain comprises a Poly(N-isopropylmethacrylamide) block between two Poly(2-Isopropyl-N-methylacrylamide) blocks.

34. An oligomeric machine, comprising:

an arrangement of molecules configured for introduction into a mammalian body, the molecules being arranged and selected such that when exposed to a prescribed temperature, the arrangement performs at least one mechanical function selected from a group consisting of vibrations, extending, rotating, lifting, pressing, ratcheting, springing, and flexing;

wherein the prescribed temperature is a normal mammalian body temperature and is below a temperature causing necrosis to mammalian cells, such that upon introduction of the molecular arrangement to the mammalian body, the molecular arrangement does not perform the mechanical function until the arrangement of molecules is exposed to a temperature at least equal to the prescribed temperature.

35. The oligomeric machine according to claim 34, further comprising a sensitizer configured to increase a local temperature.

36. The oligomeric machine according to claim 35, wherein the sensitizer is chemically attached to the arrangement of molecules.

37. The oligomeric machine according to claim 36, wherein the sensitizer includes at least one of a nanoparticle and an organic dye.

38. The oligomeric machine according to claim 35, wherein the sensitizer is configured to absorb light in the infra-red spectrum.

39. The oligomeric machine according to claim 34, wherein the oligomeric machine is chemically attached to an antibody.

40. The oligomeric machine according to claim 34, wherein the oligomeric machine is configured as a molecular linear actuator.

41. The oligomeric machine according to claim 34, wherein the oligomeric machine comprises at least one imaging agent that activates after the oligomeric machine performs a mechanical function.

42. The oligomeric machine according to claim 34, wherein the oligomeric machine is configured as a molecular tweezer, wherein the at least one mechanical function contracts at least two distal ends of the oligomeric machine to grasp an object between the distal ends of the oligomeric machine.

43. The oligomeric machine according to claim 34, wherein the oligomeric machine is chemically attached to a payload, and the oligomeric machine is configured as a molecular shuttle to move the payload.

44. The oligomeric machine according to claim 34, wherein the arrangement of molecules comprises a Poly(N-isopropylmethacrylamide) block between two Poly(2-Isopropyl-N-methylacrylamide) blocks.

45. An oligomeric machine, comprising:

a synthetic material including a first oligomeric module and a second oligomeric module joined to the first oligomeric module to form an oligomeric chain;

at least one bend or hinge location at a position of co-joinder between the first

oligomeric module and the second oligomeric module, the bend or hinge location

permitting relative flexure between the first oligomeric module and the second

oligomeric module; and

a first chemical reagent attached to the first oligomeric module;

a second chemical reagent attached to the second oligomeric module; and

wherein the oligomeric chain is formed such that in response to a

prescribed amount of energy applied thereto, the first chemical reagent and the second

chemical reagent are caused to be drawn into contact with each other and to undergo a

chemical reaction.

46. The oligomeric machine according to claim 45, wherein the chemical reaction includes a chemical bond.

47. The oligomeric machine according to claim 45, wherein the chemical reaction includes acceptance by the first chemical reagent of an electron from the second chemical reagent.

48. The oligomeric machine according to claim 45, wherein the oligomeric chain comprises a Poly(N-isopropylmethacrylamide) block between two Poly(2-Isopropyl-N-methylacrylamide) blocks.

49. An oligomeric machine, comprising:

a synthetic material including a first oligomeric module and a second oligomeric module joined to the first oligomeric module to form an oligomeric chain;

at least one bending or hinge location at a position of co-joinder between the first oligomeric module and the second oligomeric module, the bending or hinge location permitting relative flexure between the first oligomeric module and the second oligomeric module;

at least one piston element;

a substrate configured relative to the at least one piston element and the oligomeric chain such that the relative flexure between the first oligomeric module and the second oligomeric module results in mechanical interaction between at least the second oligomeric module of the oligomeric chain and the at least one piston element; and

wherein the oligomeric chain is formed such that in response to a prescribed amount of energy applied thereto, the relative flexure occurs between the first oligomeric module and the second oligomeric module in a manner causing the mechanical interaction between the second oligomeric module and the piston element, and wherein the mechanical interaction produces a mechanical force.

50. The oligomeric machine according to claim 49, wherein the piston element is at least one of a graphene nanotube, a nano-wire, or a DNA fragment.

51. The oligomeric machine according to claim 49, wherein the oligomeric chain comprises a Poly(N-isopropylmethacrylamide) block between two Poly(2-Isopropyl-N-methylacrylamide) blocks.