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1. WO2020160411 - MICROSCOPE MULTIPHOTONIQUE RAPIDE

Numéro de publication WO/2020/160411
Date de publication 06.08.2020
N° de la demande internationale PCT/US2020/016109
Date du dépôt international 31.01.2020
CIB
G02B 21/36 2006.1
GPHYSIQUE
02OPTIQUE
BÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES
21Microscopes
36aménagés pour la photographie ou la projection
CPC
G01N 2021/6463
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6463Optics
G01N 21/6458
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6456Spatial resolved fluorescence measurements; Imaging
6458Fluorescence microscopy
G01N 21/6486
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
G01N 2201/06113
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2201Features of devices classified in G01N21/00
06Illumination; Optics
061Sources
06113Coherent sources; lasers
G01N 2201/105
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2201Features of devices classified in G01N21/00
10Scanning
105Purely optical scan
G02B 21/0048
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
0036Scanning details, e.g. scanning stages
0048scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
Déposants
  • APPLIKATE TECHNOLOGIES LLC [US]/[US]
Inventeurs
  • LEVENE, Michael
  • TORRES, Richard
Mandataires
  • MEYERS, Thomas C.
  • KOCK, Annie, J.
  • LEONARDO, Mark, S.
  • HYDE, Zachary, D.
  • MAGGIN, Benjamin, D.
Données relatives à la priorité
16/523,69826.07.2019US
62/800,16101.02.2019US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) FAST MULTIPHOTON MICROSCOPE
(FR) MICROSCOPE MULTIPHOTONIQUE RAPIDE
Abrégé
(EN)
The invention provides improved systems and methods for multiphoton microscopy including pixel clocking techniques for minimizing pixel integration time and providing consistent signal intensity with maximized imaging speeds. Various systems and method are described for optimizing laser repetition rate based on dye lifetime, combining polygonal mirror scanning and stage translation, using the laser pulse signal to time pixel collection, and minimizing laser pulses and dye usage based on signal to background ratios.
(FR)
L'invention concerne des systèmes et des procédés améliorés pour la microscopie multiphotonique comprenant des techniques de synchronisation de pixels pour minimiser le temps d'intégration de pixels et fournir une intensité de signal cohérente avec des vitesses d'imagerie maximales. Divers systèmes et procédés sont décrits pour optimiser un taux de répétition laser sur la base d'une durée de vie de colorant, combiner un balayage polygonal polygonal et une translation d'étage, à l'aide du signal d'impulsion laser pour collecter des pixels temporels, et minimiser les impulsions laser et l'utilisation de colorant sur la base des rapports signal/arrière-plan.
Également publié en tant que
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