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1. WO2020118213 - MÉTHODES DE TRAITEMENT DU CANCER RÉSISTANT AUX INHIBITEURS CDK4/6


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2019/065005 265853-458831
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
06 December 2019 06 December 2018
Applicant
RADIUS PHARMACEUTICALS, INC.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61P 35/00 (2006.01)i; A61K 31/015 (2006.01)i; A61K 31/137 (2006.01)i; A61K 31/138 (2006.01)i; A61K 45/06 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61P; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, CHEM ABS Data, WPI Data, BIOSIS

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
US 2018186726 A1 (CRUSKIE JR MICHAEL PAUL [US] ET AL) 05 July 2018 (2018-07-05)
1-18
Y
paragraphs [0144], [0145], [0149], [0151], [0153]
1-42
(2)
Y
US 2018169101 A1 (HATTERSLEY GARY [US]) 21 June 2018 (2018-06-21)
1-42
claims 19-24, 26-29,32-37,42,61-62
paragraphs [0072], [0103], [0105]
(3)
Y
US 2018153828 A1 (GARNER FIONA [US] ET AL) 07 June 2018 (2018-06-07)
1-42
claims 1-17; figures 1-41; examples 1-3
paragraphs [0075] - [0078], [0090], [0093] - [0095], [0104]
(4)
Y
TEERU BIHANI ET AL, "Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER + Breast Cancer Patient-derived Xenograft Models", CLINICAL CANCER RESEARCH,Vol. 23, No. 16, 04 May 2017 (2017-05-04), page 4793-4804,
XP055669099
1-42
abstract
figure 5; table 1
(5)
X,P
Hitisha Patel ET AL, "Elacestrant (RAD1901) demonstrates anti-tumor activity in models resistant to CDK4/6 inhibitors Background", San Antonio Breast Cancer Symposium - December 4-8, 2018 08 December 2018 (2018-12-08), page 1-1,
Retrieved from the Internet:
URL:https://sabcs18.posterview.com/nosl/p/P4-13-03
XP055669913
[retrieved on  2020-02-19]
1-18,21-26,29-37,40-42
Y,P
the whole document
1-42
(6)
X,P
HITISHA K. PATEL ET AL, "Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors", BREAST CANCER RESEARCH,Vol. 21, No. 1, 01 December 2019 (2019-12-01),
XP055669859
1-18,21-26,29-37,40-42
Y,P
the whole document
1-42
(7)
Y,P
ADITYA BARDIA ET AL, "EMERALD: Phase III trial of elacestrant (RAD1901) vs endocrine therapy for previously treated ER+ advanced breast cancer", FUTURE ONCOLOGY,Vol. 15, No. 28, 20 August 2019 (2019-08-20), page 3209-3218,
XP055669881
1-42
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2018186726 A1
05 July 2018
AU 2018205285 A1
CA 3047411 A1
CN 110191707 A
EP 3565542 A1
KR 20190105030 A
US 2018186726 A1
WO 2018129419 A1
04 July 2019
12 July 2018
30 August 2019
13 November 2019
11 September 2019
05 July 2018
12 July 2018
US 2018169101 A1
21 June 2018
AU 2016256469 A1
AU 2016256470 A1
AU 2016256471 A1
BR 112017023228 A2
BR 112017023233 A2
BR 112017023269 A2
CA 2984195 A1
CA 2984200 A1
CA 2984357 A1
CN 108024540 A
CN 108024541 A
CN 108135177 A
EP 3288382 A1
EP 3288383 A1
EP 3294065 A1
HK 1251407 A1
HK 1251408 A1
HK 1251409 A1
JP 2018514549 A
JP 2018514593 A
JP 2018518529 A
KR 20180011780 A
KR 20180042155 A
KR 20180043202 A
RU 2017140674 A
RU 2017140675 A
RU 2017140676 A
SG 11201708858W A
SG 11201708860S A
SG 11201708861V A
US 2018153828 A1
US 2018169101 A1
US 2018214393 A1
US 2020038343 A1
US 2020046655 A1
WO 2016176664 A1
WO 2016176665 A1
WO 2016176666 A1
14 December 2017
14 December 2017
21 December 2017
06 November 2018
06 November 2018
06 November 2018
03 November 2016
03 November 2016
03 November 2016
11 May 2018
11 May 2018
08 June 2018
07 March 2018
07 March 2018
21 March 2018
01 February 2019
01 February 2019
01 February 2019
07 June 2018
07 June 2018
12 July 2018
02 February 2018
25 April 2018
27 April 2018
29 May 2019
29 May 2019
29 May 2019
29 November 2017
29 November 2017
29 November 2017
07 June 2018
21 June 2018
02 August 2018
06 February 2020
13 February 2020
03 November 2016
03 November 2016
03 November 2016
US 2018153828 A1
07 June 2018
AU 2016256469 A1
AU 2016256470 A1
AU 2016256471 A1
BR 112017023228 A2
BR 112017023233 A2
BR 112017023269 A2
CA 2984195 A1
CA 2984200 A1
CA 2984357 A1
CN 108024540 A
CN 108024541 A
CN 108135177 A
EP 3288382 A1
EP 3288383 A1
EP 3294065 A1
HK 1251407 A1
HK 1251408 A1
HK 1251409 A1
JP 2018514549 A
JP 2018514593 A
JP 2018518529 A
KR 20180011780 A
KR 20180042155 A
KR 20180043202 A
RU 2017140674 A
RU 2017140675 A
RU 2017140676 A
SG 11201708858W A
SG 11201708860S A
SG 11201708861V A
US 2018153828 A1
US 2018169101 A1
US 2018214393 A1
US 2020038343 A1
US 2020046655 A1
WO 2016176664 A1
WO 2016176665 A1
WO 2016176666 A1
14 December 2017
14 December 2017
21 December 2017
06 November 2018
06 November 2018
06 November 2018
03 November 2016
03 November 2016
03 November 2016
11 May 2018
11 May 2018
08 June 2018
07 March 2018
07 March 2018
21 March 2018
01 February 2019
01 February 2019
01 February 2019
07 June 2018
07 June 2018
12 July 2018
02 February 2018
25 April 2018
27 April 2018
29 May 2019
29 May 2019
29 May 2019
29 November 2017
29 November 2017
29 November 2017
07 June 2018
21 June 2018
02 August 2018
06 February 2020
13 February 2020
03 November 2016
03 November 2016
03 November 2016
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
19 February 2020
Date of mailing of the international search report:
26 February 2020
Authorized officer:
Hörtner, Michael
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