Traitement en cours

Veuillez attendre...

Paramétrages

Paramétrages

Aller à Demande

1. WO2020117918 - DÉTERMINATION DES TAUX D’ÉLÉVATION DES CORPS CÉTONIQUES CIRCULANTS DANS UN FLUIDE PHYSIOLOGIQUE

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

Claims

1. A body -worn sensor configured to measure the levels of a ketone compound circulating in a physiological fluid of a wearer and capable of generating an alert to said wearer if the level of said circulating ketone compound exceeds a pre-defined level or rate of change.

2. The device of claim 1, wherein said sensor includes at least one of an electrochemical sensor, an optical sensor, a galvanic sensor, a voltammetric sensor, an amperometric sensor, a potentiometric sensor, an impedimetric sensor, a resistive sensor, a capacitive sensor, an ultrasonic sensor, a radio-frequency sensor, or a microwave sensor.

3. The device of claim 1 , wherein said ketone compound includes at least one of acetone, acetoacetic acid, or b-hydroxybutyric acid.

4. The device of claim 1, wherein said physiological fluid includes at least one of blood, serum, plasma, interstitial fluid, dermal interstitial fluid, extracellular fluid, intracellular fluid, or cerebrospinal fluid.

5. The device of claim 1, wherein said sensor is also configured to measure glucose circulating in a physiological fluid of the wearer.

6. The device of claim 1, wherein said alert is at least one of a visual notification, audible notification, haptic notification, or a textual notification.

7. The device of claim 1, wherein said pre-defined level includes a threshold value, a value indicative of clinical ketosis, a value indicative of clinical ketoacidosis, a value indicative of metabolic ketosis, a value indicative of diabetic ketoacidosis, a value indicative of metabolic ketoacidosis, or a value indicative of nutritional ketosis.

8. The device of claim 1, wherein said rate of change includes a derivative value or a slope value.

9. A body-worn sensor configured to measure the levels of a ketone compound circulating in a physiological fluid of a wearer and capable of displaying to said wearer a continuous or quasi-continuous reading of said ketone compound circulating in said physiological fluid.

10. The device of claim 9, wherein said sensor includes at least one of an electrochemical sensor, an optical sensor, a galvanic sensor, a voltammetric sensor, an amperometric sensor, a potentiometric sensor, an impedimetrie sensor, a resistive sensor, a capacitive sensor, an ultrasonic sensor, a radio-frequency sensor, or a microwave sensor.

11. The device of claim 9, wherein said ketone compound includes at least one of acetone, acetoacetic acid, and b-hydroxybutyric acid.

12. The device of claim 9, wherein said physiological fluid includes at least one of blood, serum, plasma, interstitial fluid, dermal interstitial fluid, extracellular fluid, intracellular fluid, or cerebrospinal fluid.

13. The device of claim 9, wherein said sensor is also configured to measure glucose circulating in a physiological fluid of the wearer.

14. The device of claim 9, wherein said reading is at least one of a numerical value, a textual notification, and a symbolic notification.

15. A method of generating an alert to a wearer of a body -worn sensor, said alert indicative of a metabolic state of an elevated ketone compound.

16. The method of claim 15, wherein said alert is at least one of a visual notification, audible notification, haptic notification, or a textual notification.

17. The method of claim 15, wherein said wearable device includes at least one of a transdermal sensor, transcutaneous sensor, an intradermal sensor, an intracutaneous sensor, a subdermal sensor, or a subcutaneous sensor.

18. The method of claim 15, wherein said sensor operates by optical, electrical, or electrochemical means.

19. The method of claim 15, wherein said metabolic state includes a state of baseline health, a state of normal health, a state of ketosis, or a state of ketoacidosis.

20. The method of claim 15, wherein said ketone compound includes at least one of acetone, acetoacetic acid, or b-hydroxybutyric acid.

21. A method for determining the rising levels of circulating ketone bodies in physiological fluids, the method comprising: measuring a concentration of a ketone compound circulating in a physiological fluid of a wearer of a body -worn sensor device comprising one of an electrochemical sensor, an optical sensor, a galvanic sensor, a voltammetric sensor, an amperometric sensor, a potentiometric sensor, an impedimetric sensor, a resistive sensor, a capacitive sensor, an ultrasonic sensor, a radio-frequency sensor, or a microwave sensor; storing the measurement in a memory of the body-worn device; determining if the concentration level exceeds a pre-defmed level, threshold, or rate of change from a previous measurement; and generating an alert if the concentration level exceeds a pre-defmed level, threshold, or rate of change from a previous measurement.

22. The method according to claim 21 wherein the physiological fluid includes at least one of blood, serum, plasma, interstitial fluid, dermal interstitial fluid, extracellular fluid, intracellular fluid, or cerebrospinal fluid

23. The method according to claim 21 wherein the body -worn sensor device further comprises a processor.

24. The method according to claim 23 wherein the processor of the body-worn sensor device is also configured to measure glucose circulating in a physiological fluid of the wearer.

25. The method according to claim 21 wherein the body -worn sensor device is configured to generate the alert.

26. The method according to claim 25 wherein the alert is at least one of a visual notification, audible notification, haptic notification, or a textual notification. 27. The method according to claim 21 wherein the body -worn sensor device further comprises a wireless transceiver.

28. The method according to claim 21 wherein the body -worn sensor device further comprises a graphical user display.

29. The method according to claim 21 the body -worn sensor device further comprises at least one of a transdermal sensor, transcutaneous sensor, an intradermal sensor, an intracutaneous sensor, a subdermal sensor, or a subcutaneous sensor.

30. The method according to claim 25 wherein the alert is indicative of a metabolic state of an elevated ketone compound

31. A method of generating an alarm to a person with diabetes informing the person of an increased risk of increased and/or elevated ketone levels and alerting the person to the need for treatment to prevent progression to diabetic ketoacidosis, the method comprising: utilizing a sensor for continuous and autonomous detection of ketone levels in a physiological fluid of the person, wherein the sensor is integrated into a body -worn element having a primary purpose of the continuous measurement of another analyte; and generating an alert if the ketone level is above a pre determined threshold.

32. The method according to claim 31 wherein a simultaneous measurement of ketones and glucose is from the body-worn element in a subcutaneous adipose tissue sensor.

33. The method according to claim 31 wherein a simultaneous measurement of ketones and glucose is from the body-worn element in a intradermal sensor.

34. The method according to claim 31 wherein each of a plurality of glucose readings is continuously updated to a display to the person, and each of a plurality of ketone readings is continuously monitored but displayed to the user only on demand or when the a value exceeds a pre-determined threshold.

35. The method according to claim 31 wherein the alert is an audible alert or a tactile alert or the alert is transmitted to a designated caregiver using a remote monitoring including a plurality of cloud-based notifications.