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1. WO2020112158 - COMPRIMÉS EFFERVESCENTS COMPRENANT UN LIANT DE SUCRE CRISTALLIN ET LEURS PROCÉDÉS DE FABRICATION

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

1. An effervescent tablet comprising:

an effervescent agent comprising an acid and a base;

a sweetener comprising Stevia, Monk fruit, or a combination thereof;

a first crystalline sugar binder selected from the group consisting of crystalline dextrose, crystalline sucrose, crystalline fructose, and combinations thereof, the crystalline sugar binder being essentially free of excipients; and

a flavor agent comprising gum Arabic,

the effervescent tablet having a weight of at least 4 grams and a hardness of at least 5 kiloponds and exhibiting a disintegration time of no greater than 4 minutes and 20 seconds when tested according to the Disintegration Time Test Method.

2. The effervescent tablet of claim 1, wherein the crystalline sugar binder comprises crystalline dextrose monohydrate.

3. The effervescent tablet of claim 1, wherein the crystalline sugar binder comprises crystalline dextrose monohydrate and crystalline fructose.

4. The effervescent tablet of claim 1, wherein the tablet disintegrates in 25 °C water in no greater than 3.5 minutes.

5. The effervescent tablet of claim 1 comprising

at least 20 % by weight of the effervescent agent; and

from 20 % by weight to 55 % by weight of the crystalline sugar binder.

6. The effervescent tablet of claim 5 comprising from 0.4 % by weight to 2 % by weight of the sweetener.

7. The effervescent tablet of claim 2 comprising

at least 20 % by weight of the effervescent agent; and

from 20 % by weight to 55 % by weight of the crystalline sugar binder.

8. The effervescent tablet of claim 7 comprising from 0.4 % by weight to 2 % by weight of the sweetener.

9. The effervescent tablet of claim 5 further comprising oil.

10. The effervescent tablet of claim 5 further comprising avocado oil.

11. The effervescent tablet of claim 5 further comprising at least 0.50 % by weight oil.

12. The effervescent tablet of claim 1 having a hardness of at least 6 kiloponds.

13. The effervescent tablet of claim 1, comprising at least 1.5 % by weight of a flavor agent that comprises gum Arabic.

14. The effervescent tablet of claim 1, comprising at least 2 % by weight of a flavor agent that comprises gum Arabic.

15. The effervescent tablet of claim 1, wherein the tablet is free of flavor agents that are free of gum Arabic.

16. The effervescent tablet of claim 1 further comprising a lubricant derived from rice hulls.

17. The effervescent tablet of claim 1 further comprising a multi-component integral lubricant comprising rice hull particles, gum Arabic, sunflower oil and at least one extract of rice.

18. A method of making an effervescent tablet, the method comprising:

forming an effervescent composition by combining ingredients with mixing, the ingredients comprising

an effervescent agent comprising an acid and a base,

a sweetener comprising Stevia, Monk fruit, or a combination thereof,

a first crystalline sugar binder selected from the group consisting of crystalline dextrose, crystalline sucrose, crystalline fructose, and combinations thereof, the crystalline sugar binder being essentially free of excipients, and a flavor agent comprising gum Arabic; and

tableting the effervescent composition on a tableting press to form an effervescent tablet that has a mass of at least 4 grams and a hardness of at least 5 kiloponds and that disintegrates in 25 °C water in less than 5 minutes.

19. The method of claim 18, wherein the crystalline sugar binder comprises at least 6 % moisture.

20. The method of claim 18, wherein the crystalline sugar binder is free of excipients.

21. The method of claim 18, wherein the crystalline sugar binder exhibits an average particle size of from 140 pm to 440 pm.

22. The method of claim 18, wherein the crystalline sugar binder comprises crystalline dextrose monohydrate.

23. The method of claim 18, wherein the crystalline sugar binder comprises crystalline dextrose and crystalline fructose.

24. The method of claim 18, wherein the crystalline sugar binder comprises crystalline dextrose monohydrate and crystalline fructose.

25. The method of claim 18, wherein the effervescent tablet has a hardness of at least 6 kp.

26. The method of claim 18, wherein the ingredients further comprise a lubricant derived from rice hulls.

27. The method of claim 18, wherein the ingredients further comprise a multi-component integral lubricant comprising rice hull particles, gum Arabic, sunflower oil, and at least one extract of rice.