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1. WO2020112038 - PROCÉDÉ D'OBTENTION D'UN NANOPARTICULAIRE À ADDITIF D'ARGILE

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

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CLAIMS

1 . A method for obtaining nano-particulates used in drug delivery system characterized by comprising procedure steps of;

a) reducing a delivery component into nano-delivery component by grinding in an attritor,

b) keeping obtained nano-delivery component in water,

c) dissolving an additive polymer and a drug in acetone and mixing with the nano-delivery component kept in water,

d) dialysing the solution comprising the nano-delivery component, the additive polymer and the drug to form nano-particulate in dialysis membrane against high volume water.

2. The method for obtaining nano-particulates according to claim 1 , wherein the obtained nanoparticulates comprising a nano-delivery component in range of 17,5 - 73 % and preferably 28,08 % by weight.

3. The method for obtaining nano-particulates according to claim 1 , wherein the obtained nanoparticulates comprising an additive polymer in range of 27 - 79,5 % and preferably 70,22 % by weight.

4. The method for obtaining nano-particulates according to claim 1 , wherein the obtained nanoparticulates comprising a drug in range of 0 - 3 % and preferably 1 ,7 % by weight.

5. The method for obtaining nano-particulates according to claim 1 , wherein the procedure in said step (a) comprising steps of;

running attritor at preferably in rage of 150-450 rpm so that grinder and liquid medium are mixed thoroughly,

feeding the delivery component to preferably ¼ of attritor chamber, grinding in attritor at 2400 rpm at room temperature not less than 8 hours and preferably for 10 hours.

6. The method for obtaining nano-particulates according to claim 1 or claim 5, wherein said nano delivery component is average 30 nm in.

7. The method for obtaining nano-particulates according to claim 1 , wherein the process of keeping nano-delivery component in water in said step (b) is at least for 2 hours.

8. The method for obtaining nano-particulates according to claim 1 or claim 7, wherein obtained aqueous nano delivery component is preferably 20 ml and 0,1 % w/v.

9. The method for obtaining nano-particulates according to claim 1 , and wherein the solution comprising the additive polymer and the drug in said step (c) is preferably 5 ml.

10. The method for obtaining nano-particulates according to claim 1 , wherein the dialysis membrane operation in said step (d) is conducted at preferably 37 °C and for at least 24 hours.

1 1. The method for obtaining nano-particulates according to claim 1 , and wherein said nano-particulate is preferably 120 nm.

12. The method for obtaining nano-particulates according to claim 1 , wherein said nano delivery component is a clay mineral having layered structure and is preferably Na-MMT.

13. The method for obtaining nano-particulates according to claim 1 , wherein said additive polymer is preferably PLGA.

14. The method for obtaining nano-particulates according to claim 1 , characterized in that the obtained nanoparticulates in SA drug delivery system can be administered intravenously.