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1. WO2020112027 - MÉTHODE DE DÉTECTION DE CANCER ET/OU DE TUBERCULOSE

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CLAIMS

1. A method of detecting the presence of a cancer in a subject, the method comprising the step of detecting or measuring a panel of biomarkers comprising Hexanal, Heptanal, Octanal, Decanal, Benzaldehyde, Phenylacetaldehyde, Undecane and Benzoic acid in a sample obtained from the subject.

2. The method of claim 1, wherein an increased level of each of the biomarker as compared to a reference indicates the presence of cancer in the subject.

3. The method of claim 1 or claim 2, wherein the method further comprises detecting a biomarker selected from the group consisting of Acetophenone, Dodecanal, Acetic acid, Phenol and Acetone.

4. The method of any one of claims 1 to 3, wherein the panel of biomarkers comprises Hexanal, Heptanal, Octanal, Decanal, Dodecanal, Benzaldehyde, Phenylacetaldehyde, Phenol, Acetophenone, Undecane, Acetic acid, Acetone and Benzoic acid.

5. The method of claim 4, wherein the subject is found to have cancer or likely to have cancer if 3 or more of the following conditions are met:

a) Hexanal concentration is at least 1.2 times of the control;

b) Heptanal concentration is at least 1.5 times of the control;

c) Octanal concentration is at least 1.6 times of the control;

d) Decanal concentration is at least 1.7 times of the control;

e) Dodecanal concentration is at least 1.3 times of the control;

f) Benzaldehyde concentration is at least 1.2 times of the control;

g) Phenylacetaldehyde concentration is at least 1.2 times of the control;

h) Phenol concentration is at least 1.1 times of the control;

i) Acetophenone concentration is at least 1.2 times of the control;

j) Undecane concentration is at least 1.3 times of the control;

k) Acetic acid concentration is at least 1.2 times of the control;

l) Acetone concentration is below 0.9 times of the control; or

m) Benzoic Acid concentration is at least 2 times of the control.

6. The method of claim 4, wherein an increased level of Hexanal, Heptanal, Octanal, Decanal, Dodecanal, Benzaldehye, Phenylacetaldehyde, Phenol, Acetophenone, Undecane, Acetic acid, Benzoic acid, and a decreased level of acetone, as compared to a control indicates the presence or likelihood of cancer in the subject.

7. The method of any one of claims 1 to 6, wherein the cancer is a lung cancer.

8. The method of any one of claims 1 to 7, wherein the sample is exhaled breath.

9. The method of any one of claims 1 to 8, wherein the control is a subject or group of subjects without cancer.

10. The method of any one of claims 1 to 9, wherein the method further comprises administering an anti-cancer therapy to the subject.

11. The method of any one of claims 1 to 10, wherein the method further comprises detecting a symptom of cancer in the subject.

12. A method of detecting and treating a cancer in a subject, the method comprising the steps of :

a) detecting and measuring a panel of biomarkers comprising Hexanal, Heptanal, Octanal, Decanal, Benzaldehyde, Phenylacetaldehyde, Undecane and Benzoic in a sample obtained from the subject, and

b) administering an anti-cancer therapy to the subject found to have cancer or likely to have cancer.

13. A method of detecting the presence of tuberculosis in a subject, the method comprising the step of detecting or measuring a panel of biomarkers comprising Hexanal, Heptanal, Octanal, Decanal, Benzaldehyde, Phenylacetaldehyde, Undecane and Benzoic acid in a sample obtained from the subject.

14. The method of claim 13, wherein the method further comprises detecting a biomarker selected from the group consisting of Acetophenone, Dodecanal, Acetic acid, Phenol and Acetone.

15. The method of claim 13 or claim 14, wherein the panel of biomarkers comprises Hexanal, Heptanal, Octanal, Decanal, Dodecanal, Benzaldehyde, Phenylacetaldehyde, Phenol, Acetophenone, Undecane, Acetic acid, Acetone and Benzoic acid.

16. The method of claim 15, wherein the subject is found to have tuberculosis or likely to have tuberculosis if 3 or more of the following conditions are met:

a) Hexanal concentration is at least 1.1 times of the control;

b) Heptanal concentration is at least 1.1 times of the control;.

c) Dodecanal concentration is below 0.7 times of the control;

d) Benzaldehyde concentration is below 0.8 times of the control;

e) Phenylacetaldehyde concentration is below 0.7 times of the control;

f) Phenol concentration is below 0.7 times of the control;

g) Acetophenone concentration is at below 0.8 times of the control;

h) Acetic acid concentration is at below 0.7 times of the control group; or

i) Benzoic Acid concentration is at least 2 times of the control group.

17. The method of any one of claims 11 to 16, wherein the control is a subject or group of subjects without tuberculosis.

18. A method of detecting and treating tuberculosis in a subject, the method comprising the steps of:

a) detecting or measuring a panel of biomarkers comprising Hexanal, Heptanal, Octanal, Decanal, Benzaldehyde, Phenylacetaldehyde, Undecane and Benzoic acid in a sample obtained from the subject; and

b) administering an anti-tuberculosis therapy to the subject found to have tuberculosis or likely to have tuberculosis.

19. A method of differentiating the presence of tuberculosis from cancer in a subject, the method comprising the step of detecting or measuring a panel of biomarkers comprising Hexanal, Heptanal, Octanal, Decanal, Benzaldehyde, Phenylacetaldehyde, Undecane

and Benzoic acid in a sample obtained from the subject.

20. The method of claim 19, wherein the method further comprises detecting a biomarker selected from the group consisting of Acetophenone, Dodecanal, Acetic acid, Phenol and Acetone.

21. The method of claim 19 or claim 20, wherein the panel of biomarkers comprises Hexanal, Heptanal, Octanal, Decanal, Dodecanal, Benzaldehyde, Phenylacetaldehyde, Phenol, Acetophenone, Undecane, Acetic acid, Acetone and Benzoic acid.

22. The method of any one of claims 19 to 21, wherein the control is a subject or a group of subjects without cancer or tuberculosis.

23. The method of any one claims 19 to 22, wherein any one of the following conditions indicates the presence or likelihood of tuberculosis and not cancer:

(a) a comparable level of Octanal to control;

(b) a comparable level of Decanal to control;

(c) a Dodecanal level of less than 0.7 times of the control;

(d) a Benzaldehyde level of less than 0.8 times of the control;

(e) a Phenylacetaldehyde level of less than 0.7 times of the control,

(g) a Phenol concentration of less than 0.7 times of the control;

(h) an Acetophenone concentration of less than 0.8 times of the control; or

(i) an Acetic acid level of less than 0.7 times of the control.

24. A method of differentiating the presence of cancer from tuberculosis in a subject, the method comprising the step of detecting or measuring a panel of biomarkers comprising Hexanal, Heptanal, Octanal, Decanal, Benzaldehyde, Phenylacetaldehyde, Undecane and Benzoic acid in a sample obtained from the subject.

25. The method of claim 24, wherein the method further comprises detecting a biomarker selected from the group consisting of Acetophenone, Dodecanal, Acetic acid, Phenol and Acetone.

26. The method of claim 24 or claim 25, wherein the panel of biomarkers comprises Hexanal, Heptanal, Octanal, Decanal, Dodecanal, Benzaldehyde, Phenylacetaldehyde, Phenol, Acetophenone, Undecane, Acetic acid, Acetone and Benzoic acid.

27. The method of any one of claims 24 to 26, wherein any one of the following conditions indicates the presence or likelihood of cancer and not tuberculosis:

(a) an Octanal level of at least 1.6 times of the control;

(b) a Decanal level of at least 1.6 times of the control;

(c) a Dodecanal level of at least 1.3 times of the control;

(d) a Benzaldehyde level of at least 1.2 times of the control;

(e) a Phenylacetaldehyde level of at least 1.2 times of the control,

(g) a Phenol concentration of at least 1.1 times of the control;

(h) an Acetophenone concentration of at least 1.2 times of the control; or

(i) an Acetic acid level of at least 1.2 times of control.