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1. WO2020110009 - COMPOSÉS TÉTRAMÈRES CYCLIQUES SERVANT D'INHIBITEURS DE PROPROTÉINE CONVERTASE SUBTILISINE/KEXINE DE TYPE 9 (PCSK9) POUR LE TRAITEMENT DE TROUBLES MÉTABOLIQUES


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/IB2019/060201 PAT057962-WO-PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
26 November 2019 27 November 2018
Applicant
NOVARTIS AG
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 403/12 (2006.01)i; C07D 471/08 (2006.01)i; C07D 498/08 (2006.01)i; C07D 211/56 (2006.01)i; A61P 3/06 (2006.01)i; A61K 31/395 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D; A61P; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, CHEM ABS Data, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
A
CN 108239073 A (DEV CT BIOTECHNOLOGY) 03 July 2018 (2018-07-03)
1-48
Page 2, claim 1; page 4, claim 17: compounds PPC-017 to PPC-111.
(2)
A
US 2012252796 A1 (PINGALI HARIKISHORE [IN] ET AL) 04 October 2012 (2012-10-04)
1-48
Paragraph 2; claims.
(3)
A
TAECHALERTPAISARN ET AL., "Small Molecule Inhibitors of the PCSK9.LDLR Interaction", J. AM. CHEM. SOC.,Vol. 140, No. 9, 29 January 2018 (2018-01-29), page 3242-3249,
XP055658752
1-48
the whole document
(4)
A
YANG; MIAO, "Substitution of Gly with Ala enhanced the melanoma uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide", 03 January 2012 (2012-01-03), Vol. 22, No. 4, page 1541-1545,
XP028398210
[retrieved on  2012-01-10]
1-48
Title, page 1542, figure 1.
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
CN 108239073 A
03 July 2018
CN 108239073 A
TW 201823222 A
03 July 2018
01 July 2018
US 2012252796 A1
04 October 2012
AU 2010313068 A1
BR 112012007241 A2
CA 2775413 A1
CN 102596941 A
DK 2483266 T3
EA 201270492 A1
EP 2483266 A1
EP 2567957 A1
ES 2537652 T3
IL 218852 A
JP 5640091 B2
JP 2013506655 A
KR 20120064717 A
NZ 599513 A
PL 2483266 T3
PT 2483266 E
UA 104489 C2
US 2012252796 A1
WO 2011051961 A1
ZA 201202596 B
26 April 2012
24 September 2019
05 May 2011
18 July 2012
01 June 2015
30 November 2012
08 August 2012
13 March 2013
10 June 2015
30 July 2015
10 December 2014
28 February 2013
19 June 2012
29 November 2013
31 August 2015
30 June 2015
10 February 2014
04 October 2012
05 May 2011
26 March 2014
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
17 January 2020
Date of mailing of the international search report:
05 February 2020
Authorized officer:
Weisbrod, Thomas
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