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1. WO2020109616 - MODIFICATION DE LYMPHOCYTES T


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2019/083196 007569858
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
29 November 2019 30 November 2018
Applicant
ADAPTIMMUNE LIMITED
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 35/17 (2015.01)i; C12N 5/0783 (2010.01)i; C07K 14/725 (2006.01)i; C07K 14/705 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; C12N; C07K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, Sequence Search, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2018055140 A1 (ADAPTIMMUNE LTD [GB]) 29 March 2018 (2018-03-29)
1-4,8-10,18
Y
abstract
1-29
example 4
figure 6A
(2)
Y
WO 2018170338 A2 (HUTCHINSON FRED CANCER RES [US]) 20 September 2018 (2018-09-20)
1-29
abstract
page 24, line 15 - line 22
sequence 6
(3)
A
BETHUNE MICHAEL T ET AL, "Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,Vol. 115, No. 45, 06 November 2018 (2018-11-06), page E10702-E10711,
XP002797177
1-29
the whole document
(4)
A
SOTO CAROLINA M ET AL, "MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR", CANCER IMMUNOLOGY IMMUNOTHERAPY,Vol. 62, No. 2, February 2013 (2013-02), page 359-369,
XP002797178
1-29
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2018055140 A1
29 March 2018
AU 2017330067 A1
BR 112019005685 A2
CA 3036309 A1
CN 110325633 A
EP 3516042 A1
JP 2019528748 A
KR 20200002775 A
US 2018010095 A1
US 2018298338 A1
WO 2018055140 A1
18 April 2019
11 June 2019
29 March 2018
11 October 2019
31 July 2019
17 October 2019
08 January 2020
11 January 2018
18 October 2018
29 March 2018
WO 2018170338 A2
20 September 2018
AU 2018234830 A1
CA 3055983 A1
CN 110582299 A
EP 3595708 A2
KR 20190129082 A
SG 11201908527S A
US 2020017568 A1
WO 2018170338 A2
26 September 2019
20 September 2018
17 December 2019
22 January 2020
19 November 2019
30 October 2019
16 January 2020
20 September 2018
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
29 January 2020
Date of mailing of the international search report:
26 February 2020
Authorized officer:
Mundel, Christophe
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