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1. WO2020109506 - INHIBITEURS D'ACTIVITÉ MITOCHONDRIALE CIBLANT LE MÉTABOLISME DE CELLULE TUMORALE


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2019/082969 376871D38172
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
28 November 2019 28 November 2018
Applicant
CENTRE LEON BERARD
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 31/155 (2006.01)i; A61P 35/00 (2006.01)i; A61P 35/02 (2006.01)i; C07C 335/32 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61P; C07C
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
A
WO 0107029 A2 (KADMUS PHARMACEUTICALS INC [US]) 01 February 2001 (2001-02-01)
1-21
claims 1, 2, 12
page 28 - page 34
figure 5
page 39 - page 40
(2)
A
WO 2012047630 A2 (TEINTZE MARTIN [US]; WILKINSON ROYCE A [US]; LABIB MOHAMED [US]) 12 April 2012 (2012-04-12)
1-21
claims 20, 37
page 59
page 65; table 4
(3)
A
DOMANSKA U M ET AL, "A review on CXCR4/CXCL12 axis in oncology: no place to hide", 01 January 2013 (2013-01-01), Vol. 49, No. 1, page 219-230,
XP002724533
[retrieved on  2012-06-09]
1-21
page 226; table 2
page 227, column 2
(4)
X
ABU KHALAF R ET AL, "Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration", 01 April 2010 (2010-04-01), Vol. 45, No. 4, page 1598-1617,
XP026932335
[retrieved on  2010-01-14]
14-20
page 1606; figure 4; compound 133
(5)
X
CARMELA SATURNINO ET AL, "Antioxidant activity of thioureidic derivatives I", IL FARMACO,Vol. 58, No. 9, 01 September 2003 (2003-09-01), page 823-828,
XP055588617
14-16,19,20
page 827; table 5; compounds 2-6
(6)
A
JOYCE B. SHEPARD ET AL, "Novel guanide-substituted compounds bind to CXCR4 and inhibit breast cancer metastasis :", ANTI-CANCER DRUGS,Vol. 25, No. 1, 01 January 2014 (2014-01-01), page 8-16,
XP055588624
1-21
page 15, column 2
page 9; figure 1
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 0107029 A2
01 February 2001
AU 6230300 A
EP 1202718 A2
JP 2003525213 A
WO 0107029 A2
13 February 2001
08 May 2002
26 August 2003
01 February 2001
WO 2012047630 A2
12 April 2012
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
11 February 2020
Date of mailing of the international search report:
25 February 2020
Authorized officer:
Uryga-Polowy, V
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