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1. WO2020018935 - CONCEPTION DE NOVO DE COMMUTATEURS PROTÉIQUES


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2019/042651 18-1054-PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
19 July 2019 19 July 2018
Applicant
UNIVERSITY OF WASHINGTON
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
This International Searching Authority found multiple inventions in this international application, as follows:
1. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers in between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
2. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
3. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
4. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
5. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
6. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
7. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
8. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
9. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
10. claims: 1-34(partially)
Polypeptide comprising a helical bundle comprising between 2 and 7 alpha-helices and linkers ub between. Polypeptides having 40% identitiy to the cages disclosed herein. Polypeptides having 40% identitiy to the Keys disclosed herein. Products thereof (cell, nucleic acid, kit). A LOCKR switch comprising a cage with a structural and latch region interacting and bioactive peptides.
1.
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims.
2.
As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.
3.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:
4.
No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1-34(partially)
Remark on Protest
The additional search fees were accompanied by the applicant’s protest and, where applicable, the payment of a protest fee.
The additional search fees were accompanied by the applicant’s protest but the applicable protest fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 38/00 (2006.01)i; C07K 14/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; C07K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, Sequence Search

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2015138711 A1 (UNIV WAHINGTON [US]) 17 September 2015 (2015-09-17)
1-4
SEQ ID NO:3, Figures
& Anonymous, "Phyre 2 Results for Undefined", 22 October 2019 (2019-10-22),
Retrieved from the Internet:
URL:http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/879ccbbf15dd74a2/summary.html
XP055634685
[retrieved on  2019-10-22]
the whole document
(2)
X
DUEBER JOHN E ET AL, "Reprogramming control of an allosteric signaling switch through modular recombination", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,Vol. 301, No. 5641, 26 September 2003 (2003-09-26), page 1904-1908,
XP002779633
26
cited in the application
Figure 1, page 1.
(3)
T
LANGAN ROBERT A ET AL, "De novo design of bioactive protein switches", 24 July 2019 (2019-07-24), Vol. 572, No. 7768, page 205-210,
XP036853402
[retrieved on  2019-07-24]
(4)
X
Anonymous, "UPI0006AB52F2", 06 November 2017 (2017-11-06),
Retrieved from the Internet:
URL:https://www.uniprot.org/uniparc/UPI0006AB52F2
XP055635283
[retrieved on  2019-10-23]
9
the whole document
(5)
A
PO-SSU HUANG ET AL, "The coming of age of de novo protein design", NATURE,Vol. 537, No. 7620, 01 September 2016 (2016-09-01), page 320-327,
XP055635430
1-34
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2015138711 A1
17 September 2015
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
14 November 2019
Date of mailing of the international search report:
17 January 2020
Authorized officer:
Gómez Ortiz, Mariola
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