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International application No. Applicant's or agent's file reference
PCT/US2019/041592 126913-00720
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
12 July 2019 13 July 2018
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:

5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     C07D 401/12 (2006.01)i; C07D 401/14 (2006.01)i; C07D 413/14 (2006.01)i; C07D 417/14 (2006.01)i; A61P 25/28 (2006.01)i; A61K 31/506 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
     C07D; A61P; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, CHEM ABS Data, WPI Data


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
WO 2017007756 A1 (RODIN THERAPEUTICS INC [US]) 12 January 2017 (2017-01-12)
Abstract; claims 1, 22-33; page 15 et sequence, example numbers 107, 364, 388-390.
US 2016347761 A1 (HOLSON EDWARD [US] ET AL) 01 December 2016 (2016-12-01)
Title; abstract; claim 1: Rx = (CH2)z-aromatic ring, (CH2)z-heterocyclic ring, z = 0, 1, 2, 3; claim 11, page 152: compound 117, page 160: compound 209.
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
WO 2017007756 A1
12 January 2017
EP 3319959 A1
JP 2018525432 A
US 2018194769 A1
WO 2017007756 A1
16 May 2018
06 September 2018
12 July 2018
12 January 2017
US 2016347761 A1
01 December 2016
CA 2834548 A1
EP 2701699 A1
EP 2712655 A1
JP 6240063 B2
JP 2014523857 A
JP 2018070614 A
US 2014080800 A1
US 2014080802 A1
US 2016251351 A1
US 2016347761 A1
US 2018099977 A1
WO 2012149540 A1
01 November 2012
05 March 2014
02 April 2014
29 November 2017
18 September 2014
10 May 2018
20 March 2014
20 March 2014
01 September 2016
01 December 2016
12 April 2018
01 November 2012
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
26 August 2019
Date of mailing of the international search report:
20 September 2019
Authorized officer:
Weisbrod, Thomas
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